Farzan Nadim
Professor, Biological Sciences
- farzan.nadim@njit.edu
- 973-596-8453
- 420E Central King Building (CKB)
About Me
I am a neuroscientist. My primary interest is how neuronal circuits in the central nervous system produce behavior, and how these behaviors are modified by neuromodulatory chemicals.
My lab performs experiments, using invertebrate animals, on the generation and neuromodulation of oscillations in the central nervous system, and how these oscillations result in the control of rhythmic movements. Of particular interest to us is how the effects of endogenous chemical neuromodulators, including monoamines such as dopamine and serotonin, and peptides such as endorphin, interact to modify the output of neural circuits.
Since 2019 I have started a collaborative research to explore cerebellar interaction with the brain dopaminergic centers, and its potential effects on motor function, learning and addiction.
In addition to our experimental work, our lab has a strong history in building mathematical and computational models to explore the mechanisms and function of neural circuits. These models are part of the tool set that we use to guide our understanding of the nervous system.
My lab performs experiments, using invertebrate animals, on the generation and neuromodulation of oscillations in the central nervous system, and how these oscillations result in the control of rhythmic movements. Of particular interest to us is how the effects of endogenous chemical neuromodulators, including monoamines such as dopamine and serotonin, and peptides such as endorphin, interact to modify the output of neural circuits.
Since 2019 I have started a collaborative research to explore cerebellar interaction with the brain dopaminergic centers, and its potential effects on motor function, learning and addiction.
In addition to our experimental work, our lab has a strong history in building mathematical and computational models to explore the mechanisms and function of neural circuits. These models are part of the tool set that we use to guide our understanding of the nervous system.
Education
Ph.D.; Boston University; Mathematics; 1994
M.A.; Boston University; 1989
Website
2026 Fall Courses
BIOL 790D - DOCT DISSERTATION & RESRCH
BIOL 492 - RESEARCH & INDEPENDENT STUDY
BIOL 790E - DOCTORAL DISSERTATION
BIOL 491 - SENIOR PROJECT
BIOL 725 - INDEPENDENT STUDY I
BIOL 790A - DOCT DISSERTATION & RESRCH
BIOL 790C - DOCTORAL DISSERTN & RESRCH
BIOL 643 - BIOLOGY OF ADDICTION
BIOL 701B - MASTER'S THESIS
BIOL 792B - PRE-DOCTORAL RESEARCH
BIOL 443 - BIOL ADDICTION
BIOL 726 - INDEPENDENT STUDY II
BIOL 790B - DOCT DISSERTATION & RESRCH
BIOL 792C - PRE-DOCTORAL RESEARCH
Teaching Interests
Cellular Neurobiology
Systems Neurobiology
Neurophysiology
Biology of Reward and Addiction
Cerebellar Function
Computational Neuroscience
Systems Neurobiology
Neurophysiology
Biology of Reward and Addiction
Cerebellar Function
Computational Neuroscience
Past Courses
BIOL 443: BIOLOGY OF ADDICTION
BIOL 447: CELLULAR&SYSTEMS NEUROSC-HON
BIOL 447: CELLULAR&SYSTEMS NEUROSCIENCE
BIOL 447: SYSTEMS NEUROBIOLOGY
BIOL 447: SYSTEMS NEUROBIOLOGY - HONORS
BIOL 498: SPECIAL TOPICS IN BIOLOGY
BIOL 630: CRITICAL THINKING FOR LIFE SCI
BIOL 641: SYSTEMS NEUROSCIENCE
BIOL 643: BIOLOGY OF ADDICTION
BIOL 698: ST:
BIOL 698: ST: GRANT WRITING
BIOL 698: ST:NEUROSCIENCE
BIOL 788: ST:OSCILLATIONS IN CEN NERV SY
BIOL 788: ST:QUANTITATIVE NEUROSCIENCE LA
BIOL 788: ST:QUANTITATIVE NEUROSCIENCE LE
MATH 213: CALCULUS IIIB
MATH 222: DIFFERENTIAL EQUATIONS
MATH 337: LINEAR ALGEBRA
MATH 373: INTRO TO MATHEMATICAL BIOLOGY
MATH 792B: PRE DOCTORAL RESEARCH
Research Interests
Oscillations in the central nervous system
Rhythmic motor activity and its neuromodulation
Neurobiology of reward and addiction
Rhythmic motor activity and its neuromodulation
Neurobiology of reward and addiction
Journal Article
Xinping Li, Omar Itani, Dirk M. Bucher, Horacio G. Rotstein, Farzan Nadim. 2023. "Distinct Mechanisms Underlie Electrical Coupling Resonance and Its Interaction with Membrane Potential Resonance." Frontiers in Systems Biology, vol. 3, pp. 1122433.
Daniel Levenstein, Manny Authors, Manny Authors, Horacio G. Rotstein, Farzan Nadim, David Redish. 2023. "On the role of theory and modeling in neuroscience." The Journal of Neuroscience, vol. 43, pp. 1074-1088.
Haroon Anwar, Diana Martinez, Dirk M. Bucher, Farzan Nadim. 2022. "Inter-Animal Variability in Activity Phase Is Constrained by Synaptic Dynamics in an Oscillatory Network." eNeuro , vol. 9, no. 4.
Bemin Ghobreal, Farzan Nadim, Mesut Sahin. 2022. "Selective neural stimulation by leveraging electrophysiological differentiation and using pre-pulsing and non-rectangular waveforms." Journal of Computational Neuroscience.
Srinivas Gorur-Shandilya, Elizabeth M Cronin, Anna C Schneider, Sarah Haddad, Dirk M. Bucher, Farzan Nadim, Eve Marder. 2022. "Mapping circuit dynamics during function and dysfunction." Elife, vol. 11.
Anna C Schneider, David Fox, Omar Itani, Jorge P. Golowasch, Dirk M. Bucher, Farzan Nadim. 2021. "Frequency-Dependent Action of Neuromodulation." eNeuro , vol. 8, no. 6.
Nelly Daur, Farzan Nadim, Dirk M. Bucher. 2021. "Synaptic Dynamics Convey Differential Sensitivity to Input Pattern Changes in Two Muscles Innervated by the Same Motor Neurons." eNeuro , vol. 8, no. 6.
Horacio G. Rotstein, Farzan Nadim. 2020. "Neurons and neural networks: Computational models." Encyclopedia of Life Sciences. John Wiley \& Sons, Ltd: Chichester.
Horacio G. Rotstein, Farzan Nadim. 2019. "Membrane potential resonance arising from responses of neuronal models to oscillatory inputs in current versus voltage clamp." Biological Cybernetics, vol. 113, pp. 373–395.
Diana Martinez, Haroon Anwar, Amitabha K. Bose, Dirk M. Bucher, Farzan Nadim. "Short-Term Synaptic Dynamics Control the Activity Phase of Neurons in an Oscillatory Network." eLife.
Diana Martinez, Joseph M Santin, David Schulz, Farzan Nadim. "The differential contribution of pacemaker neurons to synaptic transmission in the pyloric network of the Jonah crab, Cancer borealis." Journal of Neurophysiology, vol. 122, no. 4, pp. 1623-1633.
X Li , Dirk M. Bucher, Farzan Nadim. 2018. "Distinct Co-Modulation Rules of Synapses and Voltage-Gated Currents Coordinate Interactions of Multiple Neuromodulators.." The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 38, no. 40, pp. 8549-8562.
Zeynep Akcay, Xinxian Huang, Farzan Nadim, Amitabha K. Bose. 2018. "Phase-locking and bistability in neuronal networks with synaptic depression." Physica D: Nonlinear Phenomena, vol. 364, pp. 8-21.
Yinbo Chen, Xinping Li, Horacio G. Rotstein, Farzan Nadim. 2016. "Membrane potential resonance frequency directly influences network frequency through gap junctions." Journal of Neurophysiology, vol. 116, pp. 1554-1563.
Y Zhang, Dirk M. Bucher, Farzan Nadim. 2017. "Ionic mechanisms underlying history-dependence of conduction delay in an unmyelinated axon.." eLife, vol. 6.
David Fox, Hua-an Tseng, Tomasz Smolinsky, Horacio G. Rotstein, Farzan Nadim. 2017. "Mechanisms of generation of membrane potential resonance in a neuron with multiple resonant ionic currents." PLoS Comp Biology.
Jorge P. Golowasch, Amitabha K. Bose, Y. Guan, D. Salloum, A. Roeser, Farzan Nadim. 2017. "A balance of outward and linear inward ionic currents is required for generation of slow-wave oscillations." Journal of Neurophysiology, vol. 118, pp. 1092-1104.
H Anwar, X Li , Dirk M. Bucher, Farzan Nadim. 2017. "Functional roles of short-term synaptic plasticity with an emphasis on inhibition.." Current opinion in neurobiology, vol. 43, pp. 71-78.
N Daur, Farzan Nadim, Dirk M. Bucher. 2016. "The complexity of small circuits: the stomatogastric nervous system.." Current opinion in neurobiology, vol. 41, pp. 1-7.
Christina Mouser, Amitabha K. Bose, Farzan Nadim. 2016. "The role of electrical coupling in generating and modulating oscillations in a neuronal network." Mathematical Biosciences, vol. 278, pp. 11-21.
Amitabha K. Bose, Jorge P. Golowasch, Yinzheng Guan, Farzan Nadim. 2014. "The role of linear and voltage-dependent ionic currents in the generation of slow wave oscillations." Journal of Computational Neuroscience, vol. 37, no. 2, pp. 229-242.
Diana Martinez, Hua-an Tseng, Farzan Nadim. 2014. "The frequency preference of neurons and synapses in a recurrent oscillatory network." J Neuroscience, vol. 34, pp. 12933-12945.
Horacio G. Rotstein, Farzan Nadim. 2014. "Frequency preference in two-dimensional neural models: a linear analysis of the interaction between resonant and amplifying currents." Journal of Computational Neuroscience, vol. 37, pp. 9-28.
Zeynep Akcay, Amitabha K. Bose, Farzan Nadim. 2014. " Effects of synaptic plasticity on phase and period locking in a network of two oscillatory neurons." J Mathematical Neuroscience, vol. 4, no. 8, pp. 29.
Horacio G. Rotstein, Farzan Nadim. 2013. "Neurons and neural networks: Computational models." Encyclopedia of Life Sciences (ohn Wiley \& Sons, Ltd: Chicheste), pp. DOI: 10.1002/9780470015902.a0000089.pub2.
Horacio G. Rotstein, Farzan Nadim. 2013. "Frequency preference in two-dimensional neural models: a linear analysis of the interaction between resonant and amplifying currents." Journal of Computational Neuroscience, vol. Online First, pp. 1 - 20.
Myongkeun Oh, Shunbing Zhao, Victor V. Matveev, Farzan Nadim. 2012. "Neuromodulatory changes in short-term synaptic dynamics may be mediated by two distinct mechanisms of presynaptic calcium entry." Journal of Computational Neuroscience, vol. 33, no. 3, pp. 573-585.
Alexander Ballo, Farzan Nadim, Dirk Bucher. 2012. "Dopamine modulation of Ih improves temporal fidelity of spike propagation in a motor axon." Journal of Neuroscience, vol. 35, no. 15, pp. 5106-5119.
A W Ballo, Farzan Nadim, Dirk M. Bucher. 2012. "Dopamine modulation of Ih improves temporal fidelity of spike propagation in an unmyelinated axon.." The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 32, no. 15, pp. 5106-19.
Farzan Nadim, Shunbing Zhou, Lian Zhao, Amitabha K. Bose. 2011. "Inhibitory feedback promotes stability in an oscillatory network." Journal of Neural Engineering, vol. 8, pp. 065001.
Shunbing Zhao, A mir Farzad Sheibanie, Myongkeun Oh, Pascale Rabbah, Farzan Nadim. 2011. "Peptide neuromodulation of synaptic dynamics in an oscillatory network." Journal of Neuroscience, vol. 31, no. 39, pp. 13991-14004.
Bruce Johnson, J M Brown, M D Kvarta, L R Schneider, Farzan Nadim, Ronald M Harris-Warrick. 2011. "Differential Modulation of Synaptic Strength and Timing Regulate Synaptic Efficacy in a Motor Network." , vol. 105, no. 1, pp. 293-304.
Hua-an Tseng, Farzan Nadim. 2010. "The membrane potential waveform of bursting pacemaker neurons is a predictor of their preferred frequency and the network cycle frequency." Journal of Neuroscience, vol. 30, no. 32, pp. 10809-10819.
Alexander Ballo, Jennifer Keene, Patricia Troy, Marie Goeritz, Farzan Nadim, Dirk Bucher. 2010. "Dopamine modulates Ih in a motor axon." Journal of Neuroscience, vol. 30, no. 25, pp. 8425-8434.
A W Ballo, J C Keene, P J Troy, M L Goeritz, Farzan Nadim, Dirk M. Bucher. 2010. "Dopamine modulates Ih in a motor axon.." The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 30, no. 25, pp. 8425-34.
Shunbing Zhao, Jorge P. Golowasch, Farzan Nadim. 2010. "Pacemaker neuron and network oscillations depend on a neuromodulator-regulated linear current." Frontiers in Behavioral Neuroscience, vol. 4, no. 21.
Nelly Daur, Farzan Nadim, Wolfgang Stein. 2009. "Regulation of motor patterns by the central spike initiation zone of a sensory neuron." European J of Neuroscience, vol. 30, pp. 808-822.
Farzan Nadim, Jorge P. Golowasch, Gladis Thomas, Adam Taylor, Christopher Khalil, Arlene Pineda, Arif Patel. 2009. "Membrane capacitance measurements revisited: dependence of capacitance value on measurement method in non-isopotential neurons." Journal of Neurophysiology, vol. 102, pp. 2161-2175.
Farzan Nadim, Vahid Tohidi. 2009. "Membrane resonance in bursting pacemaker neurons of an oscillatory network is correlated with network frequency." Journal of Neuroscience, vol. 29, no. 20, pp. 6427-6435.
Farzan Nadim, Cristina Soto-Trevino, Robert Clewley. 2009. "Dominant ionic mechanisms explored in spiking and bursting using local low-dimensional reductions of a biophysically realistic model neuron." Journal of Computational Neuroscience, vol. 26, pp. 75-90.
Farzan Nadim, Vlad Brezina, Alain Destexhe, Christiane Linster. 2008. "State dependence of network output: modeling and experiments." Journal of Neuroscience, vol. 28, pp. 11806-11813.
Juliane Gansert, Jorge P. Golowasch, Farzan Nadim. 2007. "Sustained rhythmic activity in gap- neurons depends on the diameter of coupled dendrites." Journal of Neurophysiology, vol. 98, pp. 3450-3460.
Chapter
Farzan Nadim, Xinping Li, Michael Gray, Jorge P. Golowasch. "The Role of Electrical Coupling in Rhythm Generation in Small Networks." pp. 51-78. Academic Press, 2017.
Dirk M. Bucher, Gal Haspel, Jorge P. Golowasch, Farzan Nadim. "Central Pattern Generators." pp. 1-12. eLS, John Wiley & Sons, 2015.
Amitabha K. Bose, Farzan Nadim. "Multistability Arising from Synaptic Dynamics." pp. 1-11. Springer New York, 2014.
David M Fox, Horacio G. Rotstein, Farzan Nadim. "Bursting in Neurons and Small Networks." In Jaeger, Dieter; Jung, Ranu, eds., pp. 1-17. Springer, 2014.
Jorge P. Golowasch, Farzan Nadim. "Capacitance, Membrane." In Jaeger, Dieter; Jung, Ranu, eds., pp. 1-5. Springer, 2014.
Amitabha K. Bose, Farzan Nadim. "Multistability Arising from Synaptic Dynamics." In Jaeger, Dieter; Jung, Ranu, eds., pp. 1-11. Springer, 2014.
Diana Martinez, Victor V. Matveev, Farzan Nadim. "Short-Term Synaptic Plasticity in Central Pattern Generators." In Jaeger, Dieter; Jung, Ranu, eds., pp. 1-14. Springer, 2014.
Farzan Nadim, Shunbing Zhou, Amitabha K. Bose. "A PRC description of how inhibitory feedback promotes oscillation stability." In Eds. Schultheiss, Nathan W.; Prinz, Astrid A.; Butera, Robert J., eds., pp. 399-418. Phase response curves in neuroscience, 2012.
Conference Proceeding
"The synaptic effects of ectopic spike initiation and the history dependence of axonal conduction"
Frontiers in Neuroscience, July (3rd Quarter/Summer), 2015.
Frontiers in Neuroscience, July (3rd Quarter/Summer), 2015.
"Synapses showing a preferred frequency in a reciprocally inhibitory neuronal network"
Biomed Central Neuroscience, July (3rd Quarter/Summer), 2010.
Biomed Central Neuroscience, July (3rd Quarter/Summer), 2010.
"Using feed-forward networks to infer the activity of feed-back neuronal networks"
Biomed Central Neuroscience, July (3rd Quarter/Summer), 2010.
Biomed Central Neuroscience, July (3rd Quarter/Summer), 2010.
"A mechanism underlying short-term synaptic dynamics regulated by neuromodulator based on kinetics of Ca currents"
Biomed Central Neuroscience, July (3rd Quarter/Summer), 2009.
Biomed Central Neuroscience, July (3rd Quarter/Summer), 2009.
"Approximating the phase response curves of square wave bursting neurons."
BMC Neuroscience, July (3rd Quarter/Summer), 2008.
BMC Neuroscience, July (3rd Quarter/Summer), 2008.
Other
"Dynamic Neural Networks: The Stomatogastric System"
October (4th Quarter/Autumn), 2012.
October (4th Quarter/Autumn), 2012.
"Dynamic Neural Networks: The Stomatogastric System"
November, 2011.
November, 2011.
"Dynamic Neural Networks: The Stomatogastric System"
November, 2010.
November, 2010.