Casey Diekman
Casey Diekman
Professor, Mathematical Sciences
506 Cullimore Hall (CULM)
About Me
BS from Purdue University (2002), MS and PhD from University of Michigan (2005,2010), Postdoctoral Fellow at the Mathematical Biosciences Institute at The Ohio State University (2010-2013)
Education
Ph.D.; University of Michigan; Bioinformatics; 2010
M.S.; University of Michigan; Industrial & Operations Engineering; 2005
B.S.; Purdue University; Industrial Engineering; 2002
M.S.; University of Michigan; Industrial & Operations Engineering; 2005
B.S.; Purdue University; Industrial Engineering; 2002
2025 Spring Courses
MATH 211 - CALCULUS III A
MATH 790A - DOCT DISSERTATION & RES
MATH 790A - DOCT DISSERTATION & RES
Teaching Interests
differential equations, mathematical modeling, mathematical biology
Past Courses
MATH 111: CALCULUS I
MATH 112: CALCULUS II
MATH 211: CALCULUS III A
MATH 227: MATHEMATICAL MODELING
MATH 328: MATH METHODS FOR SCI & ENGR
MATH 373: INTRO TO MATHEMATICAL BIOLOGY
MATH 373: INTRODUCTION TO MATHEMATICAL BIOLOGY
MATH 451: METHODS APPL MATH II
MATH 473: INTERMED DIFFEREN EQUATN
MATH 573: INTERMED DIFF EQUATIONS
MATH 676: ADV ORDINARY DIFFE EQ
MATH 112: CALCULUS II
MATH 211: CALCULUS III A
MATH 227: MATHEMATICAL MODELING
MATH 328: MATH METHODS FOR SCI & ENGR
MATH 373: INTRO TO MATHEMATICAL BIOLOGY
MATH 373: INTRODUCTION TO MATHEMATICAL BIOLOGY
MATH 451: METHODS APPL MATH II
MATH 473: INTERMED DIFFEREN EQUATN
MATH 573: INTERMED DIFF EQUATIONS
MATH 676: ADV ORDINARY DIFFE EQ
Research Interests
dynamical systems, mathematical neuroscience, circadian rhythms
Manuscript
“COVID-19 and silent hypoxemia in a minimal closed-loop model of the respiratory rhythm generator”
bioRxiv, April (2nd Quarter/Spring) 2023.
“Inferring parameters of pyramidal neuron excitability in mouse models of Alzheimer’s disease using biophysical modeling and deep learning”
bioRxiv, April (2nd Quarter/Spring) 2023.
“Daily electrical activity in the master circadian clock of a diurnal mammal”
bioRxiv, December 2020.
bioRxiv, April (2nd Quarter/Spring) 2023.
“Inferring parameters of pyramidal neuron excitability in mouse models of Alzheimer’s disease using biophysical modeling and deep learning”
bioRxiv, April (2nd Quarter/Spring) 2023.
“Daily electrical activity in the master circadian clock of a diurnal mammal”
bioRxiv, December 2020.
Journal Article
Casey Diekman, Amitabha Bose. 2022. “Beyond the limits of circadian entrainment: Non-24-hour sleep-wake disorder, shift work, and social jet lag.” Journal of Theoretical Biology, vol. 545, pp. 111148.
Emel Khan, Soheil Saghafi, Casey O. Diekman, Horacio G. Rotstein. 2022. “The emergence of polyglot entrainment responses to periodic inputs in vicinities of a Hopf bifurcation.” Chaos: : A journal of Nonlinear Science, vol. 32:063137.
Beatriz Bano-Otalora, Matthew J Moye, Timothy M Brown, Robert J Lucas, Casey O. Diekman, Mino D.C. Belle. 2021. “Daily electrical activity in the master circadian clock of a diurnal mammal.” eLife, vol. 10, no. e68179.
Casey O. Diekman, Jongbin Lee, Chunghun Lim, Tae Hee Han, Tomas Adreani, Matthew Moye. 2021. “The E3 ubiquitin ligase adaptor Tango10 links the core circadian clock to neuropeptide and behavioral rhythms.” Proceedings of the National Academy of Sciences, vol. 118, no. 47, pp. e2110767118.
Jen Creaser, Casey O. Diekman, Kyle Wedgwood. 2021. “Entrainment dynamics organised by global manifolds in a circadian pacemaker model.” Frontiers in Applied Mathematics and Statistics, vol. 7, no. 703359.
Emel Khan, Soheil Saghafi, Casey O. Diekman, Horacio G. Rotstein. 2022. “The emergence of polyglot entrainment responses to periodic inputs in vicinities of a Hopf bifurcation.” Chaos: : A journal of Nonlinear Science, vol. 32:063137.
Beatriz Bano-Otalora, Matthew J Moye, Timothy M Brown, Robert J Lucas, Casey O. Diekman, Mino D.C. Belle. 2021. “Daily electrical activity in the master circadian clock of a diurnal mammal.” eLife, vol. 10, no. e68179.
Casey O. Diekman, Jongbin Lee, Chunghun Lim, Tae Hee Han, Tomas Adreani, Matthew Moye. 2021. “The E3 ubiquitin ligase adaptor Tango10 links the core circadian clock to neuropeptide and behavioral rhythms.” Proceedings of the National Academy of Sciences, vol. 118, no. 47, pp. e2110767118.
Jen Creaser, Casey O. Diekman, Kyle Wedgwood. 2021. “Entrainment dynamics organised by global manifolds in a circadian pacemaker model.” Frontiers in Applied Mathematics and Statistics, vol. 7, no. 703359.
SHOW MORE
Casey O. Diekman, Ning Wei. 2021. “Circadian rhythms of early afterdepolarizations and ventricular arrhythmias in a cardiomyocyte model.” Biophysical Journal, vol. 120, pp. 319-333.
Guangyuan Liao, Casey O. Diekman, Amitabha K. Bose. 2020. “Entrainment dynamics of forced hierarchical circadian systems revealed by 2-dimensional maps.” SIAM Journal of Applied Dynamical Systems, vol. 19, no. 3.
Pyonghwa Kim, Brianna Porr, Tetsuya Mori, Yong-Sung Kim, Carl Johnson, Casey O. Diekman, Yong I. Kim. 2020. “CikA, an input pathway component, senses the oxidized quinone signal to generate phase delays in the cyanobacterial circadian clock.” Journal of Biological Rhythms.
Young Jeong, Cristiano Luis Dias, Casey O. Diekman, Helen Brochon, Pyonghwa Kim, Manpreet Kaur, Yong-Sung Kim, Hye-In Jang, Yong I. Kim. 2019. “Magnesium regulates the circadian oscillator in cyanobacteria.” Journal of Biological Rhythms, vol. 34, no. 4, pp. 380-390.
Young Mi Jeong, Cristiano Luis Dias, Casey O. Diekman, Helene Brochon, Pyonghwa Kim, Manpreet Kaur, Yong-Sung Kim, Hye-In Jang, Yong I. Kim. 2019. “Magnesium regulates the circadian oscillator in cyanobacteria. .” Journal of Biological Rhythms, vol. 34, no. 4, pp. 380-390.
Manpreet Kaur, Amy Ng, Pyonghwa Kim, Casey O. Diekman, Yong I. Kim. 2019. “CikA Modulates the Effect of KaiA on the Period of the Circadian Oscillation in KaiC Phosphorylation.” JOURNAL OF BIOLOGICAL RHYTHMS.
Mino D.C. Belle, Casey O. Diekman. 2018. “Neuronal oscillations on an ultra-slow timescale: daily rhythms in electrical activity and gene expression in the mammalian master circadian clockwork.” European Journal of Neuroscience, vol. 48, no. 8, pp. 2696-2717.
Matthew J Moye, Casey O. Diekman. 2018. “Data assimilation methods for neuronal state and parameter estimation.” Journal of Mathematical Neuroscience, vol. 8, no. 11, pp. 1-38.
Robert Kass, Shun-ichi Amari, Kensuke Arai, Emery Brown, Casey O. Diekman, Markus Diesmann, Brent Doiron, Uri Eden, Adrienne Fairhall, Grant Fiddyment, Tomoki Fukai, Sonja Grun, Matthew Harrison, Moritz Helias, Hiroyuki Nakahara, Jun-nosuke Teramae, Peter J Thomas, Mark Reimers, Jordan Rodu, Horacio G. Rotstein, Eric Shea-Brown, Hideaki Shimazaki, Shigeru Shinomoto, Byron Yu, Mark Kramer. 2018. “Computational neuroscience: mathematical and statistical perspectives.” Annual Review of Statistics and its Applications, vol. 5, no. 1, pp. 183-214.
Casey O. Diekman, Amitabha K. Bose. 2018. “Reentrainment of the circadian pacemaker during jet lag: east-west asymmetry and the effects of north-south travel.” Journal of Theoretical Biology, vol. 437, pp. 261-285.
Casey O. Diekman, Peter J Thomas, Christopher G Wilson. 2017. “Eupnea, tachypnea, and autoresuscitation in a closed-loop respiratory control model.” Journal of Neurophysiology.
Sven Wegner, Mino Belle, Alun Hughes, Casey O. Diekman, Hugh Piggins. 2017. “Delayed Cryptochrome Degradation Asymmetrically Alters the Daily Rhythm in Suprachiasmatic Clock Neuron Excitability.” Journal of Neuroscience.
Casey O. Diekman, Amitabha K. Bose. 2016. “Entrainment maps: a new tool for understanding circadian oscillator models.” Journal of Biological Rhythms, vol. 31, no. 6, pp. 598-616.
Matthieu Flourakis, Elzbieta Kula-Eversole, Alan Hutchison, Tae Hee Han, Kimberly Aranda, Devon Moose, Kevin White, Aaron Dinner, Bridget Lear, Dejian Ren, Casey O. Diekman, Indira Raman, Ravi Allada. 2015. “A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability .” Cell, vol. 162, no. 4, pp. 836-848.
Casey O. Diekman, Kohinoor Dasgupta, Vijay N Nair, K.P. Unnikrishnan, . 2014. “Discovering functional neuronal connectivity from serial patterns in spike train data.” Neural Computation, vol. 26, no. 7, pp. 1263-1297.
Casey O. Diekman, Martin Golubitsky, . 2014. “Network symmetry and binocular rivalry experiments.” The Journal of Mathematical Neuroscience, vol. 4, no. 12, pp. 29 pages.
David H Terman, Jonathan E Rubin, Casey O. Diekman, . 2013. “Irregular activity arises as a natural consequence of synaptic inhibition.” Chaos: An Interdisciplinary Journal of Nonlinear Science, vol. 23, no. 4, pp. 20 pages.
Casey O. Diekman, Mino DC Belle, Robert P Irwin, Charles N Allen, Hugh D Piggins, Daniel B Forger, . 2013. “Causes and consequences of hyperexcitation in central clock neurons.” PLOS Computational Biology, vol. 9, no. 8, pp. 11 pages.
Casey O. Diekman, Martin Golubitsky, Yunjiao Wang. 2013. “Derived patterns in binocular rivalry experiments.” Journal of Mathematical Neuroscience, vol. 3, no. 6.
Casey O. Diekman, Christopher Fall, James Lechleiter, David Terman. 2013. “Modeling the neuroprotective role of enhancing astrocyte mitochondrial metabolism during stroke.” Biophysical Journal, vol. 104, pp. 1752-1763.
Casey O. Diekman, Martin Golubitsky, Tyler McMillen, Yunjiao Wang. 2012. “Reduction and dynamics of a generalized rivalry network with two learned patterns.” SIAM Journal of Applied Dynamical Systems, vol. 11, pp. 1270-1309.
Mino Belle, Casey O. Diekman, Daniel Forger, Hugh Piggins. 2009. “Daily electrical silencing in the mammalian circadian clock.” Science, vol. 326, pp. 281-284.
Casey O. Diekman, P.S. Sastry, K.P. Unnikrishnan. 2009. “Statistical significance of sequential firing patterns in multi-neuronal spike trains.” Journal of Neuroscience Methods, vol. 182, pp. 279-284.
Casey O. Diekman, Daniel Forger. 2009. “Clustering predicted by an electrophysiological model of the suprachiasmatic nucleus.” Journal of Biological Rhythms, vol. 24, pp. 322-333.
Casey O. Diekman, W He, N Prabhu, H Cramer. 2003. “Hybrid methods for automated diagnosis of breast tumors.” Analytical and Quantitative Cytology and Histology , vol. 25, pp. 183-190.
Guangyuan Liao, Casey O. Diekman, Amitabha K. Bose. 2020. “Entrainment dynamics of forced hierarchical circadian systems revealed by 2-dimensional maps.” SIAM Journal of Applied Dynamical Systems, vol. 19, no. 3.
Pyonghwa Kim, Brianna Porr, Tetsuya Mori, Yong-Sung Kim, Carl Johnson, Casey O. Diekman, Yong I. Kim. 2020. “CikA, an input pathway component, senses the oxidized quinone signal to generate phase delays in the cyanobacterial circadian clock.” Journal of Biological Rhythms.
Young Jeong, Cristiano Luis Dias, Casey O. Diekman, Helen Brochon, Pyonghwa Kim, Manpreet Kaur, Yong-Sung Kim, Hye-In Jang, Yong I. Kim. 2019. “Magnesium regulates the circadian oscillator in cyanobacteria.” Journal of Biological Rhythms, vol. 34, no. 4, pp. 380-390.
Young Mi Jeong, Cristiano Luis Dias, Casey O. Diekman, Helene Brochon, Pyonghwa Kim, Manpreet Kaur, Yong-Sung Kim, Hye-In Jang, Yong I. Kim. 2019. “Magnesium regulates the circadian oscillator in cyanobacteria. .” Journal of Biological Rhythms, vol. 34, no. 4, pp. 380-390.
Manpreet Kaur, Amy Ng, Pyonghwa Kim, Casey O. Diekman, Yong I. Kim. 2019. “CikA Modulates the Effect of KaiA on the Period of the Circadian Oscillation in KaiC Phosphorylation.” JOURNAL OF BIOLOGICAL RHYTHMS.
Mino D.C. Belle, Casey O. Diekman. 2018. “Neuronal oscillations on an ultra-slow timescale: daily rhythms in electrical activity and gene expression in the mammalian master circadian clockwork.” European Journal of Neuroscience, vol. 48, no. 8, pp. 2696-2717.
Matthew J Moye, Casey O. Diekman. 2018. “Data assimilation methods for neuronal state and parameter estimation.” Journal of Mathematical Neuroscience, vol. 8, no. 11, pp. 1-38.
Robert Kass, Shun-ichi Amari, Kensuke Arai, Emery Brown, Casey O. Diekman, Markus Diesmann, Brent Doiron, Uri Eden, Adrienne Fairhall, Grant Fiddyment, Tomoki Fukai, Sonja Grun, Matthew Harrison, Moritz Helias, Hiroyuki Nakahara, Jun-nosuke Teramae, Peter J Thomas, Mark Reimers, Jordan Rodu, Horacio G. Rotstein, Eric Shea-Brown, Hideaki Shimazaki, Shigeru Shinomoto, Byron Yu, Mark Kramer. 2018. “Computational neuroscience: mathematical and statistical perspectives.” Annual Review of Statistics and its Applications, vol. 5, no. 1, pp. 183-214.
Casey O. Diekman, Amitabha K. Bose. 2018. “Reentrainment of the circadian pacemaker during jet lag: east-west asymmetry and the effects of north-south travel.” Journal of Theoretical Biology, vol. 437, pp. 261-285.
Casey O. Diekman, Peter J Thomas, Christopher G Wilson. 2017. “Eupnea, tachypnea, and autoresuscitation in a closed-loop respiratory control model.” Journal of Neurophysiology.
Sven Wegner, Mino Belle, Alun Hughes, Casey O. Diekman, Hugh Piggins. 2017. “Delayed Cryptochrome Degradation Asymmetrically Alters the Daily Rhythm in Suprachiasmatic Clock Neuron Excitability.” Journal of Neuroscience.
Casey O. Diekman, Amitabha K. Bose. 2016. “Entrainment maps: a new tool for understanding circadian oscillator models.” Journal of Biological Rhythms, vol. 31, no. 6, pp. 598-616.
Matthieu Flourakis, Elzbieta Kula-Eversole, Alan Hutchison, Tae Hee Han, Kimberly Aranda, Devon Moose, Kevin White, Aaron Dinner, Bridget Lear, Dejian Ren, Casey O. Diekman, Indira Raman, Ravi Allada. 2015. “A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability .” Cell, vol. 162, no. 4, pp. 836-848.
Casey O. Diekman, Kohinoor Dasgupta, Vijay N Nair, K.P. Unnikrishnan, . 2014. “Discovering functional neuronal connectivity from serial patterns in spike train data.” Neural Computation, vol. 26, no. 7, pp. 1263-1297.
Casey O. Diekman, Martin Golubitsky, . 2014. “Network symmetry and binocular rivalry experiments.” The Journal of Mathematical Neuroscience, vol. 4, no. 12, pp. 29 pages.
David H Terman, Jonathan E Rubin, Casey O. Diekman, . 2013. “Irregular activity arises as a natural consequence of synaptic inhibition.” Chaos: An Interdisciplinary Journal of Nonlinear Science, vol. 23, no. 4, pp. 20 pages.
Casey O. Diekman, Mino DC Belle, Robert P Irwin, Charles N Allen, Hugh D Piggins, Daniel B Forger, . 2013. “Causes and consequences of hyperexcitation in central clock neurons.” PLOS Computational Biology, vol. 9, no. 8, pp. 11 pages.
Casey O. Diekman, Martin Golubitsky, Yunjiao Wang. 2013. “Derived patterns in binocular rivalry experiments.” Journal of Mathematical Neuroscience, vol. 3, no. 6.
Casey O. Diekman, Christopher Fall, James Lechleiter, David Terman. 2013. “Modeling the neuroprotective role of enhancing astrocyte mitochondrial metabolism during stroke.” Biophysical Journal, vol. 104, pp. 1752-1763.
Casey O. Diekman, Martin Golubitsky, Tyler McMillen, Yunjiao Wang. 2012. “Reduction and dynamics of a generalized rivalry network with two learned patterns.” SIAM Journal of Applied Dynamical Systems, vol. 11, pp. 1270-1309.
Mino Belle, Casey O. Diekman, Daniel Forger, Hugh Piggins. 2009. “Daily electrical silencing in the mammalian circadian clock.” Science, vol. 326, pp. 281-284.
Casey O. Diekman, P.S. Sastry, K.P. Unnikrishnan. 2009. “Statistical significance of sequential firing patterns in multi-neuronal spike trains.” Journal of Neuroscience Methods, vol. 182, pp. 279-284.
Casey O. Diekman, Daniel Forger. 2009. “Clustering predicted by an electrophysiological model of the suprachiasmatic nucleus.” Journal of Biological Rhythms, vol. 24, pp. 322-333.
Casey O. Diekman, W He, N Prabhu, H Cramer. 2003. “Hybrid methods for automated diagnosis of breast tumors.” Analytical and Quantitative Cytology and Histology , vol. 25, pp. 183-190.
COLLAPSE
Conference Proceeding
“Experimental validation of a closed-loop respiratory control model using dynamic clamp”
Conf Proc IEEE Eng Med Biol Soc. , July (3rd Quarter/Summer) 2018.
“Modeling the Caenorhabditis elegans locomotion network: an opportunity in connectivity”
Society for Neuroscience, October (4th Quarter/Autumn) 2015.
“Spontaneous autoresuscitation in a model of respiratory control”
Conf Proc IEEE Eng Med Biol Soc , August 2012.
Conf Proc IEEE Eng Med Biol Soc. , July (3rd Quarter/Summer) 2018.
“Modeling the Caenorhabditis elegans locomotion network: an opportunity in connectivity”
Society for Neuroscience, October (4th Quarter/Autumn) 2015.
“Spontaneous autoresuscitation in a model of respiratory control”
Conf Proc IEEE Eng Med Biol Soc , August 2012.