Casey Diekman
Casey Diekman
Professor, Mathematical Sciences
506 Cullimore Hall (CULM)
About Me
BS from Purdue University (2002), MS and PhD from University of Michigan (2005,2010), Postdoctoral Fellow at the Mathematical Biosciences Institute at The Ohio State University (2010-2013)
Education
Ph.D.; University of Michigan; Bioinformatics; 2010
M.S.; University of Michigan; Industrial & Operations Engineering; 2005
B.S.; Purdue University; Industrial Engineering; 2002
M.S.; University of Michigan; Industrial & Operations Engineering; 2005
B.S.; Purdue University; Industrial Engineering; 2002
2024 Fall Courses
MATH 211 - CALCULUS III A
MATH 790A - DOCT DISSERTATION & RES
MATH 227 - MATHEMATICAL MODELING
MATH 792B - PRE DOCTORAL RESEARCH
MATH 790A - DOCT DISSERTATION & RES
MATH 227 - MATHEMATICAL MODELING
MATH 792B - PRE DOCTORAL RESEARCH
Teaching Interests
differential equations, mathematical modeling, mathematical biology
Past Courses
MATH 111: CALCULUS I
MATH 112: CALCULUS II
MATH 211: CALCULUS III A
MATH 227: MATHEMATICAL MODELING
MATH 328: MATH METHODS FOR SCI & ENGR
MATH 373: INTRO TO MATHEMATICAL BIOLOGY
MATH 373: INTRODUCTION TO MATHEMATICAL BIOLOGY
MATH 451: METHODS APPL MATH II
MATH 473: INTERMED DIFFEREN EQUATN
MATH 573: INTERMED DIFF EQUATIONS
MATH 676: ADV ORDINARY DIFFE EQ
MATH 112: CALCULUS II
MATH 211: CALCULUS III A
MATH 227: MATHEMATICAL MODELING
MATH 328: MATH METHODS FOR SCI & ENGR
MATH 373: INTRO TO MATHEMATICAL BIOLOGY
MATH 373: INTRODUCTION TO MATHEMATICAL BIOLOGY
MATH 451: METHODS APPL MATH II
MATH 473: INTERMED DIFFEREN EQUATN
MATH 573: INTERMED DIFF EQUATIONS
MATH 676: ADV ORDINARY DIFFE EQ
Research Interests
dynamical systems, mathematical neuroscience, circadian rhythms
Manuscript
COVID-19 and silent hypoxemia in a minimal closed-loop model of the respiratory rhythm generator
bioRxiv, April (2nd Quarter/Spring) 2023
Inferring parameters of pyramidal neuron excitability in mouse models of Alzheimer’s disease using biophysical modeling and deep learning
bioRxiv, April (2nd Quarter/Spring) 2023
Daily electrical activity in the master circadian clock of a diurnal mammal
bioRxiv, December 2020
bioRxiv, April (2nd Quarter/Spring) 2023
Inferring parameters of pyramidal neuron excitability in mouse models of Alzheimer’s disease using biophysical modeling and deep learning
bioRxiv, April (2nd Quarter/Spring) 2023
Daily electrical activity in the master circadian clock of a diurnal mammal
bioRxiv, December 2020
Journal Article
Diekman, Casey, & Bose, Amitabha (2022). Beyond the limits of circadian entrainment: Non-24-hour sleep-wake disorder, shift work, and social jet lag. Journal of Theoretical Biology, 545, 111148.
Khan, Emel , & Saghafi, Soheil, & Diekman, Casey O., & Rotstein, Horacio G. (2022). The emergence of polyglot entrainment responses to periodic inputs in vicinities of a Hopf bifurcation. Chaos: : A journal of Nonlinear Science, 32:063137,
Bano-Otalora, Beatriz, & Moye, Matthew J, & Brown, Timothy M, & Lucas, Robert J, & Diekman, Casey O., & Belle, Mino D.C. (2021). Daily electrical activity in the master circadian clock of a diurnal mammal. eLife, 10(e68179),
Diekman, Casey O., & Lee, Jongbin, & Lim, Chunghun, & Han, Tae Hee, & Adreani, Tomas, & Moye, Matthew (2021). The E3 ubiquitin ligase adaptor Tango10 links the core circadian clock to neuropeptide and behavioral rhythms. Proceedings of the National Academy of Sciences, 118(47), e2110767118.
Creaser, Jen, & Diekman, Casey O., & Wedgwood, Kyle (2021). Entrainment dynamics organised by global manifolds in a circadian pacemaker model. Frontiers in Applied Mathematics and Statistics, 7(703359),
Khan, Emel , & Saghafi, Soheil, & Diekman, Casey O., & Rotstein, Horacio G. (2022). The emergence of polyglot entrainment responses to periodic inputs in vicinities of a Hopf bifurcation. Chaos: : A journal of Nonlinear Science, 32:063137,
Bano-Otalora, Beatriz, & Moye, Matthew J, & Brown, Timothy M, & Lucas, Robert J, & Diekman, Casey O., & Belle, Mino D.C. (2021). Daily electrical activity in the master circadian clock of a diurnal mammal. eLife, 10(e68179),
Diekman, Casey O., & Lee, Jongbin, & Lim, Chunghun, & Han, Tae Hee, & Adreani, Tomas, & Moye, Matthew (2021). The E3 ubiquitin ligase adaptor Tango10 links the core circadian clock to neuropeptide and behavioral rhythms. Proceedings of the National Academy of Sciences, 118(47), e2110767118.
Creaser, Jen, & Diekman, Casey O., & Wedgwood, Kyle (2021). Entrainment dynamics organised by global manifolds in a circadian pacemaker model. Frontiers in Applied Mathematics and Statistics, 7(703359),
SHOW MORE
Diekman, Casey O., & Wei, Ning (2021). Circadian rhythms of early afterdepolarizations and ventricular arrhythmias in a cardiomyocyte model. Biophysical Journal, 120, 319-333.
Liao, Guangyuan, & Diekman, Casey O., & Bose, Amitabha K. (2020). Entrainment dynamics of forced hierarchical circadian systems revealed by 2-dimensional maps. SIAM Journal of Applied Dynamical Systems, 19(3),
Kim, Pyonghwa, & Porr, Brianna , & Mori, Tetsuya , & Kim, Yong-Sung , & Johnson, Carl , & Diekman, Casey O., & Kim, Yong I. (2020). CikA, an input pathway component, senses the oxidized quinone signal to generate phase delays in the cyanobacterial circadian clock. Journal of Biological Rhythms,
Jeong, Young, & Dias, Cristiano Luis, & Diekman, Casey O., & Brochon, Helen, & Kim, Pyonghwa, & Kaur, Manpreet, & Kim, Yong-Sung, & Jang, Hye-In, & Kim, Yong I. (2019). Magnesium regulates the circadian oscillator in cyanobacteria. Journal of Biological Rhythms, 34(4), 380-390.
Jeong, Young Mi, & Dias, Cristiano Luis, & Diekman, Casey O., & Brochon, Helene, & Kim, Pyonghwa, & Kaur, Manpreet, & Kim, Yong-Sung, & Jang, Hye-In, & Kim, Yong I. (2019). Magnesium regulates the circadian oscillator in cyanobacteria. . Journal of Biological Rhythms, 34(4), 380-390.
Kaur, Manpreet, & Ng, Amy, & Kim, Pyonghwa, & Diekman, Casey O., & Kim, Yong I. (2019). CikA Modulates the Effect of KaiA on the Period of the Circadian Oscillation in KaiC Phosphorylation. JOURNAL OF BIOLOGICAL RHYTHMS,
Belle, Mino D.C., & Diekman, Casey O. (2018). Neuronal oscillations on an ultra-slow timescale: daily rhythms in electrical activity and gene expression in the mammalian master circadian clockwork. European Journal of Neuroscience, 48(8), 2696-2717.
Moye, Matthew J, & Diekman, Casey O. (2018). Data assimilation methods for neuronal state and parameter estimation. Journal of Mathematical Neuroscience, 8(11), 1-38.
Kass, Robert, & Amari, Shun-ichi, & Arai, Kensuke, & Brown, Emery, & Diekman, Casey O., & Diesmann, Markus, & Doiron, Brent, & Eden, Uri, & Fairhall, Adrienne, & Fiddyment, Grant, & Fukai, Tomoki, & Grun, Sonja, & Harrison, Matthew, & Helias, Moritz, & Nakahara, Hiroyuki, & Teramae, Jun-nosuke, & Thomas, Peter J, & Reimers, Mark, & Rodu, Jordan, & Rotstein, Horacio G., & Shea-Brown, Eric, & Shimazaki, Hideaki, & Shinomoto, Shigeru, & Yu, Byron, & Kramer, Mark (2018). Computational neuroscience: mathematical and statistical perspectives. Annual Review of Statistics and its Applications, 5(1), 183-214.
Diekman, Casey O., & Bose, Amitabha K. (2018). Reentrainment of the circadian pacemaker during jet lag: east-west asymmetry and the effects of north-south travel. Journal of Theoretical Biology, 437, 261-285.
Diekman, Casey O., & Thomas, Peter J, & Wilson, Christopher G (2017). Eupnea, tachypnea, and autoresuscitation in a closed-loop respiratory control model. Journal of Neurophysiology,
Wegner, Sven, & Belle, Mino, & Hughes, Alun, & Diekman, Casey O., & Piggins, Hugh (2017). Delayed Cryptochrome Degradation Asymmetrically Alters the Daily Rhythm in Suprachiasmatic Clock Neuron Excitability. Journal of Neuroscience,
Diekman, Casey O., & Bose, Amitabha K. (2016). Entrainment maps: a new tool for understanding circadian oscillator models. Journal of Biological Rhythms, 31(6), 598-616.
Flourakis, Matthieu, & Kula-Eversole, Elzbieta , & Hutchison, Alan, & Han, Tae Hee, & Aranda, Kimberly , & Moose, Devon, & White, Kevin, & Dinner, Aaron, & Lear, Bridget, & Ren, Dejian , & Diekman, Casey O., & Raman, Indira, & Allada, Ravi (2015). A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability . Cell, 162(4), 836-848.
Diekman, Casey O., & Dasgupta, Kohinoor, & Nair, Vijay N, & Unnikrishnan, K.P. (2014). Discovering functional neuronal connectivity from serial patterns in spike train data. Neural Computation, 26(7), 1263-1297.
Diekman, Casey O., & Golubitsky, Martin (2014). Network symmetry and binocular rivalry experiments. The Journal of Mathematical Neuroscience, 4(12), 29 pages.
Terman, David H, & Rubin, Jonathan E, & Diekman, Casey O. (2013). Irregular activity arises as a natural consequence of synaptic inhibition. Chaos: An Interdisciplinary Journal of Nonlinear Science, 23(4), 20 pages.
Diekman, Casey O., & Belle, Mino DC, & Irwin, Robert P, & Allen, Charles N, & Piggins, Hugh D, & Forger, Daniel B (2013). Causes and consequences of hyperexcitation in central clock neurons. PLOS Computational Biology, 9(8), 11 pages.
Diekman, Casey O., & Golubitsky, Martin, & Wang, Yunjiao (2013). Derived patterns in binocular rivalry experiments. Journal of Mathematical Neuroscience, 3(6),
Diekman, Casey O., & Fall, Christopher, & Lechleiter, James, & Terman, David (2013). Modeling the neuroprotective role of enhancing astrocyte mitochondrial metabolism during stroke. Biophysical Journal, 104, 1752-1763.
Diekman, Casey O., & Golubitsky, Martin, & McMillen, Tyler, & Wang, Yunjiao (2012). Reduction and dynamics of a generalized rivalry network with two learned patterns. SIAM Journal of Applied Dynamical Systems, 11, 1270-1309.
Belle, Mino, & Diekman, Casey O., & Forger, Daniel, & Piggins, Hugh (2009). Daily electrical silencing in the mammalian circadian clock. Science, 326, 281-284.
Diekman, Casey O., & Sastry, P.S., & Unnikrishnan, K.P. (2009). Statistical significance of sequential firing patterns in multi-neuronal spike trains. Journal of Neuroscience Methods, 182, 279-284.
Diekman, Casey O., & Forger, Daniel (2009). Clustering predicted by an electrophysiological model of the suprachiasmatic nucleus. Journal of Biological Rhythms, 24, 322-333.
Diekman, Casey O., & He, W, & Prabhu, N, & Cramer, H (2003). Hybrid methods for automated diagnosis of breast tumors. Analytical and Quantitative Cytology and Histology , 25, 183-190.
Liao, Guangyuan, & Diekman, Casey O., & Bose, Amitabha K. (2020). Entrainment dynamics of forced hierarchical circadian systems revealed by 2-dimensional maps. SIAM Journal of Applied Dynamical Systems, 19(3),
Kim, Pyonghwa, & Porr, Brianna , & Mori, Tetsuya , & Kim, Yong-Sung , & Johnson, Carl , & Diekman, Casey O., & Kim, Yong I. (2020). CikA, an input pathway component, senses the oxidized quinone signal to generate phase delays in the cyanobacterial circadian clock. Journal of Biological Rhythms,
Jeong, Young, & Dias, Cristiano Luis, & Diekman, Casey O., & Brochon, Helen, & Kim, Pyonghwa, & Kaur, Manpreet, & Kim, Yong-Sung, & Jang, Hye-In, & Kim, Yong I. (2019). Magnesium regulates the circadian oscillator in cyanobacteria. Journal of Biological Rhythms, 34(4), 380-390.
Jeong, Young Mi, & Dias, Cristiano Luis, & Diekman, Casey O., & Brochon, Helene, & Kim, Pyonghwa, & Kaur, Manpreet, & Kim, Yong-Sung, & Jang, Hye-In, & Kim, Yong I. (2019). Magnesium regulates the circadian oscillator in cyanobacteria. . Journal of Biological Rhythms, 34(4), 380-390.
Kaur, Manpreet, & Ng, Amy, & Kim, Pyonghwa, & Diekman, Casey O., & Kim, Yong I. (2019). CikA Modulates the Effect of KaiA on the Period of the Circadian Oscillation in KaiC Phosphorylation. JOURNAL OF BIOLOGICAL RHYTHMS,
Belle, Mino D.C., & Diekman, Casey O. (2018). Neuronal oscillations on an ultra-slow timescale: daily rhythms in electrical activity and gene expression in the mammalian master circadian clockwork. European Journal of Neuroscience, 48(8), 2696-2717.
Moye, Matthew J, & Diekman, Casey O. (2018). Data assimilation methods for neuronal state and parameter estimation. Journal of Mathematical Neuroscience, 8(11), 1-38.
Kass, Robert, & Amari, Shun-ichi, & Arai, Kensuke, & Brown, Emery, & Diekman, Casey O., & Diesmann, Markus, & Doiron, Brent, & Eden, Uri, & Fairhall, Adrienne, & Fiddyment, Grant, & Fukai, Tomoki, & Grun, Sonja, & Harrison, Matthew, & Helias, Moritz, & Nakahara, Hiroyuki, & Teramae, Jun-nosuke, & Thomas, Peter J, & Reimers, Mark, & Rodu, Jordan, & Rotstein, Horacio G., & Shea-Brown, Eric, & Shimazaki, Hideaki, & Shinomoto, Shigeru, & Yu, Byron, & Kramer, Mark (2018). Computational neuroscience: mathematical and statistical perspectives. Annual Review of Statistics and its Applications, 5(1), 183-214.
Diekman, Casey O., & Bose, Amitabha K. (2018). Reentrainment of the circadian pacemaker during jet lag: east-west asymmetry and the effects of north-south travel. Journal of Theoretical Biology, 437, 261-285.
Diekman, Casey O., & Thomas, Peter J, & Wilson, Christopher G (2017). Eupnea, tachypnea, and autoresuscitation in a closed-loop respiratory control model. Journal of Neurophysiology,
Wegner, Sven, & Belle, Mino, & Hughes, Alun, & Diekman, Casey O., & Piggins, Hugh (2017). Delayed Cryptochrome Degradation Asymmetrically Alters the Daily Rhythm in Suprachiasmatic Clock Neuron Excitability. Journal of Neuroscience,
Diekman, Casey O., & Bose, Amitabha K. (2016). Entrainment maps: a new tool for understanding circadian oscillator models. Journal of Biological Rhythms, 31(6), 598-616.
Flourakis, Matthieu, & Kula-Eversole, Elzbieta , & Hutchison, Alan, & Han, Tae Hee, & Aranda, Kimberly , & Moose, Devon, & White, Kevin, & Dinner, Aaron, & Lear, Bridget, & Ren, Dejian , & Diekman, Casey O., & Raman, Indira, & Allada, Ravi (2015). A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability . Cell, 162(4), 836-848.
Diekman, Casey O., & Dasgupta, Kohinoor, & Nair, Vijay N, & Unnikrishnan, K.P. (2014). Discovering functional neuronal connectivity from serial patterns in spike train data. Neural Computation, 26(7), 1263-1297.
Diekman, Casey O., & Golubitsky, Martin (2014). Network symmetry and binocular rivalry experiments. The Journal of Mathematical Neuroscience, 4(12), 29 pages.
Terman, David H, & Rubin, Jonathan E, & Diekman, Casey O. (2013). Irregular activity arises as a natural consequence of synaptic inhibition. Chaos: An Interdisciplinary Journal of Nonlinear Science, 23(4), 20 pages.
Diekman, Casey O., & Belle, Mino DC, & Irwin, Robert P, & Allen, Charles N, & Piggins, Hugh D, & Forger, Daniel B (2013). Causes and consequences of hyperexcitation in central clock neurons. PLOS Computational Biology, 9(8), 11 pages.
Diekman, Casey O., & Golubitsky, Martin, & Wang, Yunjiao (2013). Derived patterns in binocular rivalry experiments. Journal of Mathematical Neuroscience, 3(6),
Diekman, Casey O., & Fall, Christopher, & Lechleiter, James, & Terman, David (2013). Modeling the neuroprotective role of enhancing astrocyte mitochondrial metabolism during stroke. Biophysical Journal, 104, 1752-1763.
Diekman, Casey O., & Golubitsky, Martin, & McMillen, Tyler, & Wang, Yunjiao (2012). Reduction and dynamics of a generalized rivalry network with two learned patterns. SIAM Journal of Applied Dynamical Systems, 11, 1270-1309.
Belle, Mino, & Diekman, Casey O., & Forger, Daniel, & Piggins, Hugh (2009). Daily electrical silencing in the mammalian circadian clock. Science, 326, 281-284.
Diekman, Casey O., & Sastry, P.S., & Unnikrishnan, K.P. (2009). Statistical significance of sequential firing patterns in multi-neuronal spike trains. Journal of Neuroscience Methods, 182, 279-284.
Diekman, Casey O., & Forger, Daniel (2009). Clustering predicted by an electrophysiological model of the suprachiasmatic nucleus. Journal of Biological Rhythms, 24, 322-333.
Diekman, Casey O., & He, W, & Prabhu, N, & Cramer, H (2003). Hybrid methods for automated diagnosis of breast tumors. Analytical and Quantitative Cytology and Histology , 25, 183-190.
COLLAPSE
Conference Proceeding
Experimental validation of a closed-loop respiratory control model using dynamic clamp
Conf Proc IEEE Eng Med Biol Soc. , July (3rd Quarter/Summer) 2018
Modeling the Caenorhabditis elegans locomotion network: an opportunity in connectivity
Society for Neuroscience, October (4th Quarter/Autumn) 2015
Spontaneous autoresuscitation in a model of respiratory control
Conf Proc IEEE Eng Med Biol Soc , August 2012
Conf Proc IEEE Eng Med Biol Soc. , July (3rd Quarter/Summer) 2018
Modeling the Caenorhabditis elegans locomotion network: an opportunity in connectivity
Society for Neuroscience, October (4th Quarter/Autumn) 2015
Spontaneous autoresuscitation in a model of respiratory control
Conf Proc IEEE Eng Med Biol Soc , August 2012