Xiaoyang Xu
Xiaoyang Xu
Professor, Chemical & Materials Engineering
362 Tiernan Hall (TIER)
About Me
Dr. Xu joined in 2014 upon finishing his joint postdoctoral training between Harvard and MIT. He completed his Ph.D. at Northwestern University under the supervision of Prof. Chad Mirkin
Education
; Harvard University; ; 2014
; Massachusetts Institute of Technology; ; 2014
Posdoctoral training; MIT; Chemical Engineering; 2014
postdoctoral training; Harvard Medical School; nanomedicine; 2014
Ph.D.; Northwestern University; Material Chemistry; 2010
B.S.; East China University of Science and Technology; ; 2000
; Massachusetts Institute of Technology; ; 2014
Posdoctoral training; MIT; Chemical Engineering; 2014
postdoctoral training; Harvard Medical School; nanomedicine; 2014
Ph.D.; Northwestern University; Material Chemistry; 2010
B.S.; East China University of Science and Technology; ; 2000
2025 Spring Courses
PHEN 701B - MASTER'S THESIS
CHE 701B - MASTERS THESIS
CHE 492 - RESEARCH & INDEP STUDY
CHE 700B - MASTERS PROJECT
MTEN 492 - RESRCH AND INDPENDENT STUDY II
MTEN 700B - MASTER'S PROJECT
MTEN 790A - DOCT DISSERTATION & RES
PHEN 725 - INDEPENDENT STUDY
CHE 705 - INDEPENDENT STUDY I
CHE 706 - INDEPENDENT STUDY II
PHEN 698 - ST: BIOPHARMACEUTICS
MTEN 725 - INDEPENDENT STUDY I
MTEN 792 - PRE-DOCTORAL RESEARCH
CHE 491 - RESEARCH & INDEP STUDY
CHE 790A - DOCT DISSERTATION & RES
MTEN 491 - RESEARCH & INDEPENDENT STUDY I
MTEN 701B - MASTERS THESIS
MTEN 726 - INDEPENDENT STUDY II
CHE 792 - PRE-DOCTORAL RESEARCH
CHE 701C - MASTERS THESIS
CHE 701B - MASTERS THESIS
CHE 492 - RESEARCH & INDEP STUDY
CHE 700B - MASTERS PROJECT
MTEN 492 - RESRCH AND INDPENDENT STUDY II
MTEN 700B - MASTER'S PROJECT
MTEN 790A - DOCT DISSERTATION & RES
PHEN 725 - INDEPENDENT STUDY
CHE 705 - INDEPENDENT STUDY I
CHE 706 - INDEPENDENT STUDY II
PHEN 698 - ST: BIOPHARMACEUTICS
MTEN 725 - INDEPENDENT STUDY I
MTEN 792 - PRE-DOCTORAL RESEARCH
CHE 491 - RESEARCH & INDEP STUDY
CHE 790A - DOCT DISSERTATION & RES
MTEN 491 - RESEARCH & INDEPENDENT STUDY I
MTEN 701B - MASTERS THESIS
MTEN 726 - INDEPENDENT STUDY II
CHE 792 - PRE-DOCTORAL RESEARCH
CHE 701C - MASTERS THESIS
Teaching Interests
material science, nanomedicine, biomaterials, thermodynamics
Past Courses
CHE 230: CHEM ENGINEER THERMODYNAMICS I
CHE 230: CHEMICAL ENGINEERING THERMODYNAMICS I
CHE 230W: CHE THERMODYNAMICS I WORKSHOP
CHE 702: INTRO THERAP & DRUG DEL
CHE 702: INTRODUCTION TO DRUG DELIVERY
CHE 702: SELECTED TOPICS IN CHEMICAL ENGINEERING II
CHE 702: ST: BIOMATERIALS
CHE 702: ST: BIOPHARMACEUTICS AND NANOMEDICINE
CHE 791: GRADUATE SEMINAR
CHE 230: CHEMICAL ENGINEERING THERMODYNAMICS I
CHE 230W: CHE THERMODYNAMICS I WORKSHOP
CHE 702: INTRO THERAP & DRUG DEL
CHE 702: INTRODUCTION TO DRUG DELIVERY
CHE 702: SELECTED TOPICS IN CHEMICAL ENGINEERING II
CHE 702: ST: BIOMATERIALS
CHE 702: ST: BIOPHARMACEUTICS AND NANOMEDICINE
CHE 791: GRADUATE SEMINAR
Research Interests
His research focus is the development of novel biomaterials and nanotechnologies for a variety of medical applications including diagnosis, bioimaging, drug delivery, and regenerative medicine. He looks at both fundamental and applied questions in the cross-disciplinary fields of biomaterials and medicine in order to develop novel therapeutic methods for the treatment of cancer, obesity, and cardiovascular disease.
Journal Article
Xiaoyang Xu. 2022. "Identification and Characterization of a Novel Long Noncoding RNA that Regulates Osteogenesis in Diet-Induced Obesity Mice." Front. Cell Dev. Biol. .
Xiaoyang Xu. 2022. "Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge." Science Advances.
Xiaoyang Xu. "Lipid-Polymer Hybrid “Particle-in-Particle” Nanostructure Gene Delivery Platform Explored for Lyophilizable DNA and mRNA COVID-19 Vaccines." .
Xiaoyang Xu. 2022. "Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy." Bioactive Materials .
Xiaoyang Xu. 2021. "An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing." Bioactive Materials .
Xiaoyang Xu. 2022. "Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge." Science Advances.
Xiaoyang Xu. "Lipid-Polymer Hybrid “Particle-in-Particle” Nanostructure Gene Delivery Platform Explored for Lyophilizable DNA and mRNA COVID-19 Vaccines." .
Xiaoyang Xu. 2022. "Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy." Bioactive Materials .
Xiaoyang Xu. 2021. "An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing." Bioactive Materials .
SHOW MORE
Xiaoyang Xu. 2021. "Injectable hydrogel mediated delivery of gene-engineered adipose-derived stem cells for enhanced osteoarthritis treatment." Biomaterials Science .
Xiaoyang Xu. 2021. "Next‐Generation Vaccines: Nanoparticle‐Mediated DNA and mRNA Delivery." Adv. Healthcare Mater..
Xiaoyang Xu. 2021. "Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis." Front. Cell Dev Biol. .
Yunghao Tsou. 2019. "Nanotechnology-mediated drug delivery for the treatment of obesity and its related comorbidities." Adv. Healthcare Mater. .
Zhanxian Li. 2019. "Lysosome-targeting NIR ratiometric luminecent upcoversion nanoprobe T toward arginine." Sensors and Actuators B: Chemical .
Xiaoyang Xu, Jing Li, Mengchu Zhou, J. Xu, J. Cao. 2018. "Accelerated Two-Stage Particle Swarm Optimization for Clustering Not-Well-Separated Data." IEEE Transactions on Systems, Man, and Cybernetics: Systems.
Maochong Hu. 2018. "Boron-doped graphene nanosheets-supported Pt: highly active and selective catalyst for low temperature H2-SCR." Nanoscale.
Yunghao Tsou. 2018. "Dopant-free hydrogels with intrinsic photoluminescent and biodegradable properties." Adv. Funct. Mater. .
Xin Bai. 2018. "Bioactive hydrogels for bone regeneration." Bioactive Materials, vol. 3.
Xiaoyang Xu. 2017. "Drug delivery to the brain across the blood-brain barrier using nanomaterials." .
Xiaoyang Xu. 2017. "Synthesis of PLGA/lipid hybrid nanoparticles for siRNA delivery using emulsion method." .
W Ho, X Q Zhang, Xiaoyang Xu. 2016. "Biomaterials in siRNA Delivery: A Comprehensive Review.." Advanced healthcare materials.
Xiaoyang Xu. 2016. "Hydrogel as a bioactive material to regulate stem cell fate." Bioactive Materials, vol. 1, no. 1.
X Gao, Y H Tsou, M Garis, Haidong Huang, Xiaoyang Xu. 2016. "Highly specific colorimetric detection of DNA oxidation biomarker using gold nanoparticle/triplex DNA conjugates.." Nanomedicine : nanotechnology, biology, and medicine, vol. 12, no. 7, pp. 2101-2105.
Y Xue, Xiaoyang Xu, X Q Zhang, O C Farokhzad, R Langer. 2016. "Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles.." Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 20, pp. 5552-7.
Xiaoyang Xu. 2015. "An intestinal Trojan horse for gene delivery." Nanoscale, vol. 7, pp. 4354-4360.
Xiaoyang Xu. 2015. "Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment." Proc Natl Acad Sci , vol. 112, no. 25, pp. 7779-7784.
Xiaoyang Xu, W Ho, X Zhang, N Bertrand, O Farokhzad. 2015. "Cancer nanomedicine: from targeted delivery to combination therapy.." Trends in molecular medicine, vol. 21, no. 4, pp. 223-32.
Xiaoyang Xu. 2021. "Next‐Generation Vaccines: Nanoparticle‐Mediated DNA and mRNA Delivery." Adv. Healthcare Mater..
Xiaoyang Xu. 2021. "Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis." Front. Cell Dev Biol. .
Yunghao Tsou. 2019. "Nanotechnology-mediated drug delivery for the treatment of obesity and its related comorbidities." Adv. Healthcare Mater. .
Zhanxian Li. 2019. "Lysosome-targeting NIR ratiometric luminecent upcoversion nanoprobe T toward arginine." Sensors and Actuators B: Chemical .
Xiaoyang Xu, Jing Li, Mengchu Zhou, J. Xu, J. Cao. 2018. "Accelerated Two-Stage Particle Swarm Optimization for Clustering Not-Well-Separated Data." IEEE Transactions on Systems, Man, and Cybernetics: Systems.
Maochong Hu. 2018. "Boron-doped graphene nanosheets-supported Pt: highly active and selective catalyst for low temperature H2-SCR." Nanoscale.
Yunghao Tsou. 2018. "Dopant-free hydrogels with intrinsic photoluminescent and biodegradable properties." Adv. Funct. Mater. .
Xin Bai. 2018. "Bioactive hydrogels for bone regeneration." Bioactive Materials, vol. 3.
Xiaoyang Xu. 2017. "Drug delivery to the brain across the blood-brain barrier using nanomaterials." .
Xiaoyang Xu. 2017. "Synthesis of PLGA/lipid hybrid nanoparticles for siRNA delivery using emulsion method." .
W Ho, X Q Zhang, Xiaoyang Xu. 2016. "Biomaterials in siRNA Delivery: A Comprehensive Review.." Advanced healthcare materials.
Xiaoyang Xu. 2016. "Hydrogel as a bioactive material to regulate stem cell fate." Bioactive Materials, vol. 1, no. 1.
X Gao, Y H Tsou, M Garis, Haidong Huang, Xiaoyang Xu. 2016. "Highly specific colorimetric detection of DNA oxidation biomarker using gold nanoparticle/triplex DNA conjugates.." Nanomedicine : nanotechnology, biology, and medicine, vol. 12, no. 7, pp. 2101-2105.
Y Xue, Xiaoyang Xu, X Q Zhang, O C Farokhzad, R Langer. 2016. "Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles.." Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 20, pp. 5552-7.
Xiaoyang Xu. 2015. "An intestinal Trojan horse for gene delivery." Nanoscale, vol. 7, pp. 4354-4360.
Xiaoyang Xu. 2015. "Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment." Proc Natl Acad Sci , vol. 112, no. 25, pp. 7779-7784.
Xiaoyang Xu, W Ho, X Zhang, N Bertrand, O Farokhzad. 2015. "Cancer nanomedicine: from targeted delivery to combination therapy.." Trends in molecular medicine, vol. 21, no. 4, pp. 223-32.
COLLAPSE
Chapter
Xiaoyang Xu. "Injectable Hydrogels for Vascular Tissue Engineering." "Methods in Molecular Biology, 2022," 2022.
Xiaoyang Xu. "Green Nanomaterials Preparation: Sustainable Methods and Approaches." RCS , 2015.
Xiaoyang Xu. "Green Nanomaterials Preparation: Sustainable Methods and Approaches." RCS , 2015.