Pier Alexandre Champagne
Pier Alexandre Champagne
(Pier Alexandre Champagne) Assistant Professor, Chemistry and Environmental Science
354 Tiernan Hall (TIER)
Education
Ph.D.; Université Laval; Organic Chemistry; 2015
B.S.; Université Laval; Chemistry; 2010
B.S.; Université Laval; Chemistry; 2010
Past Courses
CHEM 243: ORGANIC CHEMISTRY I
CHEM 244: ORGANIC CHEMISTRY II
CHEM 244: ORGANIC CHEMISTRY II - HONORS
CHEM 244A: ORGANIC CHEMISTRY II LAB
CHEM 605: ADV ORGANIC CHEM: STRUCTR
CHEM 605: ADVANCED ORGANIC CHEMISTRY I: STRUCTURE
CHEM 791: GRADUATE SEMINAR
CHEM 792B: PRE-DOCTORAL RESEARCH
CHEM 792C: PRE-DOCTORAL RESEARCH
EVSC 791: ENVIRONMENTAL SCIENCE SEMINAR
CHEM 244: ORGANIC CHEMISTRY II
CHEM 244: ORGANIC CHEMISTRY II - HONORS
CHEM 244A: ORGANIC CHEMISTRY II LAB
CHEM 605: ADV ORGANIC CHEM: STRUCTR
CHEM 605: ADVANCED ORGANIC CHEMISTRY I: STRUCTURE
CHEM 791: GRADUATE SEMINAR
CHEM 792B: PRE-DOCTORAL RESEARCH
CHEM 792C: PRE-DOCTORAL RESEARCH
EVSC 791: ENVIRONMENTAL SCIENCE SEMINAR
In Progress
Experimental and computational investigations on elemental sulfur for organic chemistry
Experimental and computational studies on the reaction mechanisms and reactivity profile of elemental sulfur. This project targets the reactivity of sulfur with nucleophiles, elucidating mechanisms of known reactions and developing new chemical transformations for the synthesis of value-added sulfur-containing molecules.
Mechanisms and origins of selectivity for phase-transfer catalyzed reactions
In this computational project, state-of-the-art Density Functional Theory (DFT) calculations are used to elucidate the mechanisms and origins of enantioselectivity of asymmetric transformations catalyzed by chiral phase-transfer catalysts. Specifically, we are interested in reactions that do not use enolate nucleophiles. The goal is to develop a comprehensive model of reactivity and selectivity for these catalysts, allowing further rational developments in the field.
Rearrangements and reactivity of complex non-classical cations
Non-classical cations are unique chemical structures that are poorly understood, but participate in many reactions involving carbocations. In this project, DFT calculations are used to probe the various rearrangements and reactivity patterns of such carbocations, in addition to probing the role of substitution on these pathways.
Experimental and computational studies on the reaction mechanisms and reactivity profile of elemental sulfur. This project targets the reactivity of sulfur with nucleophiles, elucidating mechanisms of known reactions and developing new chemical transformations for the synthesis of value-added sulfur-containing molecules.
Mechanisms and origins of selectivity for phase-transfer catalyzed reactions
In this computational project, state-of-the-art Density Functional Theory (DFT) calculations are used to elucidate the mechanisms and origins of enantioselectivity of asymmetric transformations catalyzed by chiral phase-transfer catalysts. Specifically, we are interested in reactions that do not use enolate nucleophiles. The goal is to develop a comprehensive model of reactivity and selectivity for these catalysts, allowing further rational developments in the field.
Rearrangements and reactivity of complex non-classical cations
Non-classical cations are unique chemical structures that are poorly understood, but participate in many reactions involving carbocations. In this project, DFT calculations are used to probe the various rearrangements and reactivity patterns of such carbocations, in addition to probing the role of substitution on these pathways.
Journal Article
Sharma, Jyoti , & Champagne, Pier Alexandre (2024). Mechanisms of the Gewald synthesis of 2-aminothiophenes from elemental sulfur. The Journal of Organic Chemistry, 89, 9609-9619.
Larmore, Sean P, & Champagne, Pier Alexandre (2024). Substituent effects on the equilibria between cyclopropylcarbinyl, bicyclobutonium, homoallyl, and cyclobutyl cations. The Journal of Organic Chemistry, 89, 8146-8156.
Fosnacht, Kaylin, & Sharma, Jyoti, & Champagne, Pier Alexandre, & Pluth, Michael D (2024). Transpersulfidation or H2S Release? Understanding the Landscape of Persulfide Chemical Biology. Journal of the American Chemical Society, 146, 18689-18698.
Larmore, Sean P, & Champagne, Pier Alexandre (2023). Cyclopropylcarbinyl-to-Homoallyl Carbocation Equilibria Influence the Stereospecificity in the Nucleophilic Substitution of Cyclopropylcarbinols. Journal of Organic Chemistry, 88(11), 6947-6954.
Newton, Turner D., & Li, Keyan, & Sharma, Jyoti, & Champagne, Pier, & Pluth, Michael D. (2023). Direct hydrogen selenide (H2Se) release from activatable selenocarbamates. Chemical Science, 14(27), 7581-7588.
Larmore, Sean P, & Champagne, Pier Alexandre (2024). Substituent effects on the equilibria between cyclopropylcarbinyl, bicyclobutonium, homoallyl, and cyclobutyl cations. The Journal of Organic Chemistry, 89, 8146-8156.
Fosnacht, Kaylin, & Sharma, Jyoti, & Champagne, Pier Alexandre, & Pluth, Michael D (2024). Transpersulfidation or H2S Release? Understanding the Landscape of Persulfide Chemical Biology. Journal of the American Chemical Society, 146, 18689-18698.
Larmore, Sean P, & Champagne, Pier Alexandre (2023). Cyclopropylcarbinyl-to-Homoallyl Carbocation Equilibria Influence the Stereospecificity in the Nucleophilic Substitution of Cyclopropylcarbinols. Journal of Organic Chemistry, 88(11), 6947-6954.
Newton, Turner D., & Li, Keyan, & Sharma, Jyoti, & Champagne, Pier, & Pluth, Michael D. (2023). Direct hydrogen selenide (H2Se) release from activatable selenocarbamates. Chemical Science, 14(27), 7581-7588.
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