Pier Alexandre Champagne
Pier Alexandre Champagne
(Pier Alexandre Champagne) Assistant Professor, Chemistry and Environmental Science
354 Tiernan Hall (TIER)
Education
Ph.D.; Université Laval; Organic Chemistry; 2015
B.S.; Université Laval; Chemistry; 2010
B.S.; Université Laval; Chemistry; 2010
2024 Spring Courses
CHEM 700B - MASTERS PROJECT
CHEM 790A - DOCTORAL DISSERTATION
CHEM 590 - GRADUATE CO-OP WORK EXPER I
CHEM 701B - MASTERS THESIS
CHEM 701C - MASTERS THESIS
CHEM 792B - PRE-DOCTORAL RESEARCH
CHEM 491 - RESEARCH & INDEP STUDY I
CHEM 391 - RESEARCH AND INDEPENDENT STUDY
CHEM 492 - RESEARCH & INDEP STUDY
CHEM 725 - INDEPENDENT STUDY I
CHEM 726 - INDEPENDENT STUDY II
CHEM 790A - DOCTORAL DISSERTATION
CHEM 590 - GRADUATE CO-OP WORK EXPER I
CHEM 701B - MASTERS THESIS
CHEM 701C - MASTERS THESIS
CHEM 792B - PRE-DOCTORAL RESEARCH
CHEM 491 - RESEARCH & INDEP STUDY I
CHEM 391 - RESEARCH AND INDEPENDENT STUDY
CHEM 492 - RESEARCH & INDEP STUDY
CHEM 725 - INDEPENDENT STUDY I
CHEM 726 - INDEPENDENT STUDY II
Past Courses
CHEM 243: ORGANIC CHEMISTRY I
CHEM 244: ORGANIC CHEMISTRY II
CHEM 244: ORGANIC CHEMISTRY II - HONORS
CHEM 244A: ORGANIC CHEMISTRY II LAB
CHEM 605: ADV ORGANIC CHEM: STRUCTR
CHEM 605: ADVANCED ORGANIC CHEMISTRY I: STRUCTURE
CHEM 791: GRADUATE SEMINAR
CHEM 792B: PRE-DOCTORAL RESEARCH
CHEM 792C: PRE-DOCTORAL RESEARCH
EVSC 791: ENVIRONMENTAL SCIENCE SEMINAR
CHEM 244: ORGANIC CHEMISTRY II
CHEM 244: ORGANIC CHEMISTRY II - HONORS
CHEM 244A: ORGANIC CHEMISTRY II LAB
CHEM 605: ADV ORGANIC CHEM: STRUCTR
CHEM 605: ADVANCED ORGANIC CHEMISTRY I: STRUCTURE
CHEM 791: GRADUATE SEMINAR
CHEM 792B: PRE-DOCTORAL RESEARCH
CHEM 792C: PRE-DOCTORAL RESEARCH
EVSC 791: ENVIRONMENTAL SCIENCE SEMINAR
In Progress
Experimental and computational investigations on elemental sulfur for organic chemistry
Experimental and computational studies on the reaction mechanisms and reactivity profile of elemental sulfur. This project targets the reactivity of sulfur with nucleophiles, elucidating mechanisms of known reactions and developing new chemical transformations for the synthesis of value-added sulfur-containing molecules.
Mechanisms and origins of selectivity for phase-transfer catalyzed reactions
In this computational project, state-of-the-art Density Functional Theory (DFT) calculations are used to elucidate the mechanisms and origins of enantioselectivity of asymmetric transformations catalyzed by chiral phase-transfer catalysts. Specifically, we are interested in reactions that do not use enolate nucleophiles. The goal is to develop a comprehensive model of reactivity and selectivity for these catalysts, allowing further rational developments in the field.
Phase-transfer catalyzed functionalization of enones
Developement of new nucleophilic functionalization of enones and alpha,beta-unsaturated carbonyl compounds using weak nucleophiles. These methodologies are then extended to enantioselective transformation using cationic phase-transfer catalysts such as those derived from Cinchona alkaloids.
Rearrangements and reactivity of complex non-classical cations
Non-classical cations are unique chemical structures that are poorly understood, but participate in many reactions involving carbocations. In this project, DFT calculations are used to probe the various rearrangements and reactivity patterns of such carbocations, in addition to probing the role of substitution on these pathways.
Experimental and computational studies on the reaction mechanisms and reactivity profile of elemental sulfur. This project targets the reactivity of sulfur with nucleophiles, elucidating mechanisms of known reactions and developing new chemical transformations for the synthesis of value-added sulfur-containing molecules.
Mechanisms and origins of selectivity for phase-transfer catalyzed reactions
In this computational project, state-of-the-art Density Functional Theory (DFT) calculations are used to elucidate the mechanisms and origins of enantioselectivity of asymmetric transformations catalyzed by chiral phase-transfer catalysts. Specifically, we are interested in reactions that do not use enolate nucleophiles. The goal is to develop a comprehensive model of reactivity and selectivity for these catalysts, allowing further rational developments in the field.
Phase-transfer catalyzed functionalization of enones
Developement of new nucleophilic functionalization of enones and alpha,beta-unsaturated carbonyl compounds using weak nucleophiles. These methodologies are then extended to enantioselective transformation using cationic phase-transfer catalysts such as those derived from Cinchona alkaloids.
Rearrangements and reactivity of complex non-classical cations
Non-classical cations are unique chemical structures that are poorly understood, but participate in many reactions involving carbocations. In this project, DFT calculations are used to probe the various rearrangements and reactivity patterns of such carbocations, in addition to probing the role of substitution on these pathways.
Journal Article
Larmore, Sean P, & Champagne, Pier Alexandre (2023). Cyclopropylcarbinyl-to-Homoallyl Carbocation Equilibria Influence the Stereospecificity in the Nucleophilic Substitution of Cyclopropylcarbinols. Journal of Organic Chemistry, 88(11), 6947-6954.
Newton, Turner D., & Li, Keyan, & Sharma, Jyoti, & Champagne, Pier, & Pluth, Michael D. (2023). Direct hydrogen selenide (H2Se) release from activatable selenocarbamates. Chemical Science, 14(27), 7581-7588.
Sharma, Jyoti, & Champagne, Pier (2023). Mechanisms of the Reaction of Elemental Sulfur and Polysulfides with Cyanide and Phosphines. Chemistry – A European Journal, 29(32),
Ribéraud, Maxime, & Porte, Karine, & Chevalier, Arnaud, & Madegard, Léa, & Rachet, Aurélie, & Delaunay-Moisan, Agnès, & Vinchon, Florian, & Thuéry, Pierre, & Chiappetta, Giovanni, & Champagne, Pier, & Pieters, Grégory, & Audisio, Davide, & Taran, Frédéric (2023). Fast and Bioorthogonal Release of Isocyanates in Living Cells from Iminosydnones and Cycloalkynes. Journal of the American Chemical Society, 145(4), 2219-2229.
Sharma, Jyoti, & Champagne, Pier Alexandre (2022). Benchmark of density functional theory methods for the study of organic polysulfides. Journal of Computational Chemistry, 43(32), 2131-2138.
Newton, Turner D., & Li, Keyan, & Sharma, Jyoti, & Champagne, Pier, & Pluth, Michael D. (2023). Direct hydrogen selenide (H2Se) release from activatable selenocarbamates. Chemical Science, 14(27), 7581-7588.
Sharma, Jyoti, & Champagne, Pier (2023). Mechanisms of the Reaction of Elemental Sulfur and Polysulfides with Cyanide and Phosphines. Chemistry – A European Journal, 29(32),
Ribéraud, Maxime, & Porte, Karine, & Chevalier, Arnaud, & Madegard, Léa, & Rachet, Aurélie, & Delaunay-Moisan, Agnès, & Vinchon, Florian, & Thuéry, Pierre, & Chiappetta, Giovanni, & Champagne, Pier, & Pieters, Grégory, & Audisio, Davide, & Taran, Frédéric (2023). Fast and Bioorthogonal Release of Isocyanates in Living Cells from Iminosydnones and Cycloalkynes. Journal of the American Chemical Society, 145(4), 2219-2229.
Sharma, Jyoti, & Champagne, Pier Alexandre (2022). Benchmark of density functional theory methods for the study of organic polysulfides. Journal of Computational Chemistry, 43(32), 2131-2138.
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