Pier Alexandre Champagne
(Pier Alexandre Champagne)
Assistant Professor, Chemistry and Environmental Science
354 Tiernan Hall (TIER)
Education
Ph.D.
; Université Laval
; Organic Chemistry
; 2015
B.S. ; Université Laval ; Chemistry ; 2010
B.S. ; Université Laval ; Chemistry ; 2010
2025 Fall Courses
CHEM 700B - MASTERS PROJECT
CHEM 790A - DOCTORAL DISSERTATION
CHEM 590 - GRADUATE CO-OP WORK EXPER I
CHEM 701B - MASTERS THESIS
EVSC 701B - MASTER'S THESIS
EVSC 726 - INDEPENDENT STUDY II
EVSC 792B - PRE-DOCTORAL RESEARCH
CHEM 701C - MASTERS THESIS
CHEM 792B - PRE-DOCTORAL RESEARCH
EVSC 701C - MASTER'S THESIS
CHEM 491 - RESEARCH & INDEP STUDY I
EVSC 592 - GRADUATE WORK EXPERIENCE II
CHEM 391 - RESEARCH AND INDEPENDENT STUDY
EVSC 790A - DOCTORAL DISSERTATION
FRSC 491 - RESEARCH & INDEP STUDY I
CHEM 492 - RESEARCH & INDEP STUDY
CHEM 725 - INDEPENDENT STUDY I
EVSC 591 - GRADUATE WORK EXPERIENCE I
EVSC 700B - MASTER'S PROJECT
CHEM 726 - INDEPENDENT STUDY II
EVSC 725 - INDEPENDENT STUDY I
CHEM 243 - ORGANIC CHEMISTRY I
CHEM 591 - GRADUATE CO-OP WORK EXPER II
CHEM 790A - DOCTORAL DISSERTATION
CHEM 590 - GRADUATE CO-OP WORK EXPER I
CHEM 701B - MASTERS THESIS
EVSC 701B - MASTER'S THESIS
EVSC 726 - INDEPENDENT STUDY II
EVSC 792B - PRE-DOCTORAL RESEARCH
CHEM 701C - MASTERS THESIS
CHEM 792B - PRE-DOCTORAL RESEARCH
EVSC 701C - MASTER'S THESIS
CHEM 491 - RESEARCH & INDEP STUDY I
EVSC 592 - GRADUATE WORK EXPERIENCE II
CHEM 391 - RESEARCH AND INDEPENDENT STUDY
EVSC 790A - DOCTORAL DISSERTATION
FRSC 491 - RESEARCH & INDEP STUDY I
CHEM 492 - RESEARCH & INDEP STUDY
CHEM 725 - INDEPENDENT STUDY I
EVSC 591 - GRADUATE WORK EXPERIENCE I
EVSC 700B - MASTER'S PROJECT
CHEM 726 - INDEPENDENT STUDY II
EVSC 725 - INDEPENDENT STUDY I
CHEM 243 - ORGANIC CHEMISTRY I
CHEM 591 - GRADUATE CO-OP WORK EXPER II
Past Courses
CHEM 243: ORGANIC CHEMISTRY I
CHEM 244: ORGANIC CHEMISTRY II
CHEM 244: ORGANIC CHEMISTRY II - HONORS
CHEM 244A: ORGANIC CHEMISTRY II LAB
CHEM 605: ADV ORGANIC CHEM: STRUCTR
CHEM 605: ADVANCED ORGANIC CHEMISTRY I: STRUCTURE
CHEM 791: GRADUATE SEMINAR
CHEM 792B: PRE-DOCTORAL RESEARCH
CHEM 792C: PRE-DOCTORAL RESEARCH
EVSC 791: ENVIRONMENTAL SCIENCE SEMINAR
CHEM 244: ORGANIC CHEMISTRY II
CHEM 244: ORGANIC CHEMISTRY II - HONORS
CHEM 244A: ORGANIC CHEMISTRY II LAB
CHEM 605: ADV ORGANIC CHEM: STRUCTR
CHEM 605: ADVANCED ORGANIC CHEMISTRY I: STRUCTURE
CHEM 791: GRADUATE SEMINAR
CHEM 792B: PRE-DOCTORAL RESEARCH
CHEM 792C: PRE-DOCTORAL RESEARCH
EVSC 791: ENVIRONMENTAL SCIENCE SEMINAR
In Progress
Experimental and computational investigations on polysulfides
Experimental and computational studies on the reaction mechanisms and reactivity profile of polysulfides and elemental sulfur. This project targets the reactivity of polysulfides with electrophiles or nucleophiles under biological conditions. We are making photoactivated donors of reactive sulfur species to study their reactivity and biological roles. We are studying elemental sulfur with nucleophiles, elucidating mechanisms of known reactions.
Mechanisms and origins of selectivity for phase-transfer catalyzed reactions
In this computational project, state-of-the-art Density Functional Theory (DFT) calculations are used to elucidate the mechanisms and origins of enantioselectivity of asymmetric transformations catalyzed by chiral phase-transfer catalysts. Specifically, we are interested in reactions that do not use enolate nucleophiles. The goal is to develop a comprehensive model of reactivity and selectivity for these catalysts, allowing further rational developments in the field.
Rearrangements and reactivity of complex non-classical cations
Non-classical cations are unique chemical structures that are poorly understood, but participate in many reactions involving carbocations. In this project, DFT calculations are used to probe the various rearrangements and reactivity patterns of such carbocations, in addition to probing the role of substitution on these pathways. We are collaborating with experts in the field, such as Nuno Maulide (U. Vienna).
Experimental and computational studies on the reaction mechanisms and reactivity profile of polysulfides and elemental sulfur. This project targets the reactivity of polysulfides with electrophiles or nucleophiles under biological conditions. We are making photoactivated donors of reactive sulfur species to study their reactivity and biological roles. We are studying elemental sulfur with nucleophiles, elucidating mechanisms of known reactions.
Mechanisms and origins of selectivity for phase-transfer catalyzed reactions
In this computational project, state-of-the-art Density Functional Theory (DFT) calculations are used to elucidate the mechanisms and origins of enantioselectivity of asymmetric transformations catalyzed by chiral phase-transfer catalysts. Specifically, we are interested in reactions that do not use enolate nucleophiles. The goal is to develop a comprehensive model of reactivity and selectivity for these catalysts, allowing further rational developments in the field.
Rearrangements and reactivity of complex non-classical cations
Non-classical cations are unique chemical structures that are poorly understood, but participate in many reactions involving carbocations. In this project, DFT calculations are used to probe the various rearrangements and reactivity patterns of such carbocations, in addition to probing the role of substitution on these pathways. We are collaborating with experts in the field, such as Nuno Maulide (U. Vienna).
Journal Article
Yanmei Li, Emily Kryvorutsky, Yuanwei Zhang, Pier Alexandre Champagne.
2025. "Efficient release of COS/H2S via BODIPY-based photocaged thionocarbamates."
Journal of Materials Chemistry B , vol. 13 , pp. 11046-11054.
Diana M Castaneda-Bagatella, Pier Alexandre Champagne. 2025. "General Model of Enantioselectivity for Phase Transfer-Catalyzed Conjugate Cyclization of Ureas." ChemCatChem , pp. e01170.
Cory Rogers, Anu Pradeep, Layla Galiano, Ariel Kelley, Ramkumar Varadharajan, Ken Belmore, Logan Whitt, Yanmei Li, Pier Alexandre Champagne, Vaidhyanathan Ramamurthy, Slias Blackstock. 2024. "Dynamic Covalent and Noncovalent Assembly of o-Nitrosocumene in Organic Solvents and Water." Chemical Communications , vol. 60 , pp. 13899-13902.
Jyoti Sharma, Pier Alexandre Champagne. 2024. "Mechanisms of the Gewald synthesis of 2-aminothiophenes from elemental sulfur." The Journal of Organic Chemistry , vol. 89 , pp. 9609-9619.
Sean P Larmore, Pier Alexandre Champagne. 2024. "Substituent effects on the equilibria between cyclopropylcarbinyl, bicyclobutonium, homoallyl, and cyclobutyl cations." The Journal of Organic Chemistry , vol. 89 , pp. 8146-8156.
Diana M Castaneda-Bagatella, Pier Alexandre Champagne. 2025. "General Model of Enantioselectivity for Phase Transfer-Catalyzed Conjugate Cyclization of Ureas." ChemCatChem , pp. e01170.
Cory Rogers, Anu Pradeep, Layla Galiano, Ariel Kelley, Ramkumar Varadharajan, Ken Belmore, Logan Whitt, Yanmei Li, Pier Alexandre Champagne, Vaidhyanathan Ramamurthy, Slias Blackstock. 2024. "Dynamic Covalent and Noncovalent Assembly of o-Nitrosocumene in Organic Solvents and Water." Chemical Communications , vol. 60 , pp. 13899-13902.
Jyoti Sharma, Pier Alexandre Champagne. 2024. "Mechanisms of the Gewald synthesis of 2-aminothiophenes from elemental sulfur." The Journal of Organic Chemistry , vol. 89 , pp. 9609-9619.
Sean P Larmore, Pier Alexandre Champagne. 2024. "Substituent effects on the equilibria between cyclopropylcarbinyl, bicyclobutonium, homoallyl, and cyclobutyl cations." The Journal of Organic Chemistry , vol. 89 , pp. 8146-8156.
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