Hao Chen
Professor, Department of Chemistry and Environmental Science
- hao.chen.2@njit.edu
- 232 York Center (YORK)
Education
Ph.D.; Purdue University; 2005
Website
2026 Fall Courses
CHEM 701B - MASTERS THESIS
CHEM 726 - INDEPENDENT STUDY II
CHEM 391 - RESEARCH AND INDEPENDENT STUDY
CHEM 492 - RESEARCH & INDEP STUDY
EVSC 592 - GRADUATE WORK EXPERIENCE II
EVSC 700B - MASTER'S PROJECT
EVSC 701C - MASTER'S THESIS
EVSC 790A - DOCTORAL DISSERTATION
EVSC 701B - MASTER'S THESIS
EVSC 726 - INDEPENDENT STUDY II
EVSC 792B - PRE-DOCTORAL RESEARCH
EVSC 591 - GRADUATE WORK EXPERIENCE I
EVSC 725 - INDEPENDENT STUDY I
CHEM 591 - GRADUATE CO-OP WORK EXPER II
CHEM 700B - MASTERS PROJECT
CHEM 701C - MASTERS THESIS
CHEM 725 - INDEPENDENT STUDY I
CHEM 792B - PRE-DOCTORAL RESEARCH
FRSC 491 - RESEARCH & INDEP STUDY I
CHEM 491 - RESEARCH & INDEP STUDY I
CHEM 590 - GRADUATE CO-OP WORK EXPER I
CHEM 790A - DOCTORAL DISSERTATION
FRSC 475 - FORENSIC CHEMISTRY & LAB
Teaching Interests
Analytical chemistry, Forensic chemistry
Past Courses
CHEM 221: ANALYTICAL CHEM METHODS
CHEM 221: ANALYTICAL CHEMICAL METHODS
CHEM 222: ANALYTICAL CHEMISTRY
CHEM 714: PHARMACEUTICAL ANALYSIS
EVSC 791: ENVIRONMENTAL SCIENCE SEMINAR
FRSC 475: FORENSIC CHEMISTRY
FRSC 475: FORENSIC CHEMISTRY & LAB
Research Interests
Analytical chemistry, mass spectrometry, electrochemistry, forensic chemistry, environmental chemistry
Journal Article
Xuemei Chen, Krishnaben V. Sabhaya, Bryan Liu, Gabrielle Bonifacio, Yongqing Yang, Hao Chen, Yuanwei Zhang. 2026. "BODIPY-based photouncaging – green light triggered dual cargo molecule release." Chem. Comm., vol. 62, pp. 6128-6131.
Kai-Yuan Chiu, Yun-Chen Hsieh, Hsin-Bai Zou, Che-Wei Chien, Wei-Kai Wu, Hsien-Li Kao, Hao Chen, Cheng-Chih Hsu. 2026. "High-Throughput Quantitation of Plasma Trimethylamine N‑oxide Using Desorption Electrospray Ionization Mass Spectrometry for Rapid Cardiovascular Disease Screening." J. Am. Soc. Mass Spectrom., vol. 37, pp. 135–142.
Kai-Yuan Chiu, Yun-Chen Hsieh, Hsin-Bai Zou, Che-Wei Chien, Wei-Kai Wu, Hsien-Li Kao, Hao Chen, Cheng-Chih Hsu. 2026. "High-Throughput Quantitation of Plasma Trimethylamine N‑oxide Using Desorption Electrospray Ionization Mass Spectrometry for Rapid Cardiovascular Disease Screening." J. Am. Soc. Mass Spectrom., vol. 37, pp. 135–142.
Md. Tanim-Al Hassan, Amani Zoabi, Anna Morshin, Hao Chen, Katherine Margulis. 2026. "Mass Spectrometry Imaging Coupled with Pixel-Level Absolute Quantification of Olanzapine and Its Metabolite by Coulometric Mass Spectrometry." J. Am. Soc. Mass Spectrom., vol. 37, pp. 1366–1375.
Mohammad Borna Bahramsari, Md Tanim-Al Hassan, Hao Chen, Alexei Khalizov. 2026. "Reactive Paper Spray Mass Spectrometry Enables Speciation of Trace Levels of Mercuric Halides." Analytical Chemistry, vol. 98, pp. 17453–17465.
Xuemei Chen, Krishnaben Sabhaya, Bryan Liu, Gabrielle Bonifacio, Yongqing Yang, Hao Chen, Yuanwei Zhang. 2026. "BODIPY-based photouncaging – green light triggered dual cargo molecule release." Chem. Commun. , vol. 62, pp. 6128.
Md Tanim-Al Hassan, Yongling Ai, Bhavya Deshaboina, Timothy Yaroshuk, Arjun Sharma, Quentin Young, Howard D. Dewald, Hao Chen. 2025. "Absolute Quantitation of Phosphopeptides and Glycopeptides Using Coulometric Mass Spectrometry (CMS)." ACS Measurement Science Au, vol. 5, pp. 559–571.
Huifang Yao, Dan Zhou, Sophie Van Sickle, Haihong Zhou, Hao Chen, David G. McLaren, Steve Previs. 2025. "Microdroplet Mass Spectrometry Enables Rapid and Sensitive Measurement of Glucose Homeostasis for Elucidating Mechanism of Drug Action." Analytical Chemistry, no. 97, pp. 19480−19488.
Aidan Looby, Lalu Venigalla, Wenjun Hou, Mengyuan Xiao, Yongqing Yang, Hao Chen, Brad Carrow. 2025. "On-Demand Access to Palladium Oxidative Addition Complexes (OACs) from a Stable Organopalladate Salt." Organometallics, vol. 44, pp. 704–711.
Huifang Yao, Seamus Kelley, Dan Zhou, Sophie VanSickle, Sheng-Ping Wang, Jennifer Piesvaux, Haihong Zhou, Hao Chen, David McKenney, David McLaren, Jeanine Ballard, Stephen Previs. 2025. "Quantifying protein kinetics in vivo: Influence of precursor dynamics on product labeling." American Journal of Physiology-Endocrinology and Metabolism, vol. 328, pp. E173-E185.
Mengyuan Xiao, Yongqing Yang, Hanin Alahmadi, Allison Harbolic, Gina M. Moreno, Terry Yu, Jerry Liu, Alex Guo, Genoa R. Warner, Phoebe A. Stapleton , Hao Chen. 2025. "Rapid Detection of Microplastics and Nanoplastics in Seconds by Mass Spectrometry." Journal of Hazardous Materials , no. 493, pp. 138322.
Yongqing Yang, Mengyuan Xiao, Jim Lau, Mike Knierman, Hui Zhao, Xi Qiu, Karen Luo, John Sausen, Harsha P. Gunawardena, Hao Chen. 2025. "Ultrafast Microdroplet Digestion of Antibodies with Fc-Silencing Mutations." Analytical Chemistry, vol. 97, pp. 12813–12823.
Yongqing Yang, Md Tanim-Al Hassan, Juana Perez Sanchez, Quentin A. Young, Richard N. Zare, Hao Chen. 2025. "Ultrafast PFAS degradation using oxidant-containing microdroplets." Chem Comm, vol. 61, pp. 17629–17632.
Praneeth Ivan Joel FNU, Md. Tanim-Al Hassan, Timothy Yaroshuk, Yongling Ai, Hao Chen. 2024. "Absolute Quantitation of Peptides and Proteins by Coulometric Mass Spectrometry After Derivatization." Int. J. Mass Spectrom., vol. 495, pp. 117153.
Hao Chen, Yongling Ai, . 2024. "Development of Coulometric Mass Spectrometry for Absolute Chemical Quantitation." Encyclopedia of Analytical Chemistry, vol. DOI: 10.1002/9780470027318.a9811..
Jingwen Wei, Thong Pham, Emamanuel Attah, Mengjia Liu, Timothy Yaroshuk, Hao Chen, Lukasz Wojtas, Xiaodong Shi. 2024. "Gold-Catalyzed Diyne-Ene Condensation for the Synthesis of Dense-Function Benzenes (DFBs) through Formal [3+3] Approach with Amide as the Critical Co-Catalyst." Angew. Chem. Int. Ed., vol. in press.
Francis J. Osonga, Gaddi B. Eshun, Huize Xue, Stephen Kurilla, Md. Tanim-Al Hassan, Areej Qamar, Hao Chen, Omowunmi A. Sadik. 2024. "IMPACT: Innovative (nano)Materials and Processes for Advanced Catalytic Technologies to Detect and Degrade PFOA in Water." Chemosphere, vol. 364, pp. 143057.
Kai-Yuan Chiu, Yongling Ai, Md. Tanim-Al Hassan, Xuanwen Li, Harsha Gunawardena, Hao Chen. 2024. "Kai-Yuan Chiu, Yongling Ai, Md. Tanim-Al Hassan, Xuanwen Li, Harsha Gunawardena, Hao Chen*, Standards-Free Absolute Quantitation of Oxidizable Glycopeptides by Coulometric Mass Spectrometry." J. Am. Soc. Mass Spectrom., vol. 35, pp. 1441−1450.
Matrika Bhattarai, Qi Wang, Md. Tanim-Al Hassan, Zawar Hussain, Hao Chen, Ahmed Faik. 2024. "New insights on beta-glycan synthases using in vitro GT-array (i-GT-ray) platform." Plant Physiology and Biochemistry, vol. in press.
Matrika Bhattarai, Qi Wang, Tasleem Javaid, Akshayaa Venkataraghavan, Md Tanim-Al Hassan, Malcolm O’Neil, Li Tan, Hao Chen, Ahmed Faik. 2024. "Streamlining enzyme assays of glycosyltransferases activity using in vitro GT-array (i-GT-ray) platform: Application to family GT37 fucosyltransferases." Journal of Biological Chemistry, vol. 300, pp. 105734.
Chen Wu, Sandra Goodrow, Hao Chen, Mengyan Li. 2024. "Distinctive biotransformation and biodefluorination of 6:2 versus 5:3 fluorotelomer carboxylic acids by municipal activated sludge." Water Research, vol. 254.
Md Tanim Hassan, Xingzhi Chen, Praneeth Ivan Fnu, Francis J. Osonga, Omowunmi Sadik, Mengyan Li, Hao Chen. 2024. "Rapid detection of per- and polyfluoroalkyl substances (PFAS) using paper spray-based mass spectrometry." Journal of Hazardous Materials, vol. 465.
Hao Chen, Chun Wang, , . 2023. "Converting waste expanded polystyrene into higher-value-added hyper-crosslinked porous polymer for rapid and high-efficient adsorption of aflatoxins." Journal of Cleaner Production, vol. 408, pp. 137102.
Zhaoxiong Wan, Shupei Yu, Qi Wang, Karthik Sambath, Roshena Harty, Xiangshan Liu, Hao Chen, Chen Wang, Xuan Liu, Yuanwei Zhang. 2023. "Far-red BODIPY-based oxime esters: photo-uncaging and drug delivery." Journal of Materials Chemistry B, vol. 11, no. 41, pp. 9889--9893.
Shupei Yu, Ojasvita Reddy, Alperen Abaci, Yongling Ai, Yanmei Li, Hao Chen, Murat Guvendiran, Kevin Belfield, Yuanwei Zhang. 2023. "Novel BODIPY-based photobase generators for photo-induced polymerization." ACS Applied Materials & Interfaces, vol. 15, pp. 45281–45289.
Yanmei Li, Diana M. Castañeda-Bagatella, Dhyeyi Kakkad, Yongling Ai, Hao Chen, Pier Alexandre Champagne. 2023. "Synthetic and mechanistic study on the conjugate isothiocyanation of enones with trimethylsilyl isothiocyanate ." Organic & Biomolecular Chemistry, vol. 21, pp. 9583-9590.
Yanmei Li, Diana Marlén Castaneda Bagatella, Dhyeyi Kakkad, Yongling Ai, Hao Chen, Pier Alexandre Champagne. 2023. "Synthetic and mechanistic study on the conjugate isothiocyanation of enones with trimethylsilyl isothiocyanate." Organic & Biomolecular Chemistry, vol. 21, pp. 9583-9590.
Theresa Gewering, Deepali Waghray, Kristian Parey, Hendrik Jung, Nghi N.B. Tran, Joel Zapata, Pengyi Zhao, Hao Chen, Dovile Januliene, Gerhard Hummer, Ina L. Urbatsch, Arne Moeller, Qinghai Zhang. 2023. "Tracing the substrate translocation mechanism in P-glycoprotein." eLife, vol. 12, pp. RP90174 .
Yucong Shen, Frank Y. Shih, Hao Chen. 2023. "Drug toxicity prediction by machine learning approaches." Pattern Recognition and Artificial Intelligence, vol. 37, no. 8, pp. 2351013 (14 pages).
Aida López Ruiz, Mengyuan Xiao, Asmitha Sathya, Nicole Piccininni, Guangliang Liu, Noshin Siddiq, Hao Chen, Kathleen McEnnis. 2023. "Influence of particle z-potential and experimental procedure on protein corona formation and multicomponent aggregation." AIChE Journal, pp. e18237.
Hao Chen, Yongling Ai, Harsha Gunawardena. 2023. "Rapid Characterization of Antibodies via Automated Flow Injection Coupled with Microdroplet Reactions and Native Mass Spectrometry." Analytical Chemistry, vol. 95, pp. 3340–3348.
Zhaoxiong Wan, Shupei Yu, Qi Wang, John Tobia, Hao Chen, Zhanjun Li, Xuan Liu, Yuanwei Zhang. 2022. "A BODIPY-Based Far-Red-Absorbing Fluorescent Probe for Hypochlorous Acid Imaging." ChemPhotoChem, pp. e202100250.
Qi Wang, Zhijian Liu, Yong Liu, Hao Chen. 2022. "Absolute Quantitation of N-Nitrosamines by Coulometric Mass Spectrometry without Using Standards." J. Am. Soc. Mass Spectrom., vol. 33, pp. 875–884.
Wen Zhang, Qi Wang, Hao Chen. 2022. "Challenges in Characterization of Nanoplastics in the Environment." Front. Environ. Sci. Eng., vol. 16, pp. 11.
Yongling Ai, Jeffrey Xu, Harsha P. Gunawardena, Richard Zare, Hao Chen. 2022. "Investigation of Tryptic Protein Digestion in Microdroplet and in Bulk Solution." J. Am. Soc. Mass Spectrom., vol. 33, pp. 1238–1249.
Chen Wu, Hao Chen, Mengyan Li. 2022. "Rapid Quantitative Analysis and Suspect Screening of Per-and Polyfluorinated Alkyl Substances (PFAS) in Aqueous Film-Forming Foams (AFFFs) and Municipal Wastewater Samples by Nano-ESI-HRMS." Water Research, vol. 219, pp. 118542.
Yongling Ai, Harsha P. Gunawardena, Xuanwen Li, Yong-Ick Yong, Howard Dewald, Hao Chen. 2022. "Standard-Free Absolute Quantitation of Antibody Deamidation Degradation and Host Cell Proteins by Coulometric Mass Spectrometry." Anal. Chem., vol. 94, pp. 12490−12499.
Chen Wu, Qi Wang, Hao Chen, Mengyan Li. 2022. "Rapid quantitative analysis and suspect screening of per-and polyfluorinated alkyl substances (PFASs) in aqueous film-forming foams (AFFFs) and municipal wastewater samples by Nano-ESI-HRMS." Water Research, vol. 219.
Hao Chen, Yongling Ai, Pengyi Zhao, Praneeth Ivan Joel FNU. 2021. "Absolute Quantitation of Tryptophan-Containing Peptides and Amyloid Beta Peptide Fragments by Coulometric Mass Spectrometry." J. Am. Soc. Mass Spectrom., vol. 32, pp. 1771-1779.
Hao Chen, Jia Li, Richard Zare. 2021. "Accelerated oxidation of organic sulfides by microdroplet chemistry." Journal of Organic Chemistry, vol. 86, pp. 5011–5015.
Hao Chen, Xiaodong Shi. 2021. "Alkyne Trifunctionalization via Divergent Gold Catalysis: Combining p-Acid Activation, Vinyl-Gold Addition and Redox Catalysis." J. Am. Chem. Soc., vol. 143, pp. 4074–4082.
Hao Chen, Qi Wang, Qile Wang, Nan Zheng, Richard Zare, Carlos Pacheco, Yasmine M. Mohamed, Yuexiang Zhang. 2021. "Electrocatalytic Redox Neutral [3+2] Annulation of N-Cyclopropylanilines and Alkenes." Chemical Science, vol. 12, pp. 969 - 975.
Hao Chen, Michal Szostak. 2021. "Evaluation of Cyclic Amides as Activating Groups in N–C Bond Cross-Coupling: Discovery of N-Acyl-δ- Valerolactams as Effective Twisted Amide Precursors for Cross-Coupling Reactions." Journal of Organic Chemistry, vol. 86, pp. 10455–10466.
Hao Chen, Kai Luo, Richard Zare. 2021. "Location of carbon-carbon double bonds in unsaturated lipids using microdroplet mass spectrometry." Analyst, vol. 146, pp. 2550-2558.
Hao Chen, Pengyi Zhao, Richard Zare, Harsha Gunawardena. 2021. "Microdroplet Ultrafast Reactions Speed Antibody Characterization." Analytical Chemistry, vol. 93, pp. 3997–4005.
Hao Chen, Xiaoqin Zhong, Richard Zare. 2021. "Ultrafast Enzymatic Digestion of Deoxyribonucleic Acid in Aqueous Microdroplets for Sequence Discrimination and Identification." QRB Discovery , vol. 2:e4, pp. 1–8.
Pengyi Zhao, Qi Wang, Manpreet Kaur, Yong-I. Kim, Howard D Dewald, Olivier Mozziconacci, Yong Liu, Hao Chen. 2020. "Absolute Quantitation of Proteins by Coulometric Mass Spectrometry." Analytical Chemistry, vol. in press.
Karthik Sambath, Zhaoxiong Wan, Qi Wang, , Hao Chen, Yuanwei Zhang. 2020. "BODIPY-Based Photoacid Generators (PAGs) for Light-Induced Cationic Polymerization." Organic Letters, vol. in press.
Chengyuan Liu, Qi Wang, Brian E Hivick, Yongling Ai, Pier Champagne, Yang Pan, Hao Chen. 2020. "Capture of Electrochemically Generated Fleeting Carbazole Radical Cations and Elucidation of Carbazole Dimerization Mechanism by Mass Spectrometry." Analytical Chemistry, vol. 92, no. 23, pp. 15291--15296.
Xiaowei Song, Hao Chen. 2020. "Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI) for Tissue Analysis." Encyclopedia of Analytical Chemistry, vol. in press.
Jin Wang, Chiyu Wei, Xuming Li, Pengyi Zhao, Chuan Shan, Lukasz Wojtas, Hao Chen, Xiaodong Shi. 2020. "Gold Redox Catalysis with Selenium Cation as Mild Oxidant." Chemistry-An European Journal, vol. in press.
M. Rahman, C. Liu, E. Bisz, B. Dziuk, R. Lalancette, Qi Wang, , Hao Chen, R. Szostak, M. Szostak. 2020. "N-Acyl-Glutarimides: Effect of Glutarimide Ring on the Structures of Fully Perpendicular Twisted Amides and N–C Bond Cross-Coupling." Journal of Organic Chemistry, vol. in press.
Kai Luo, Jia Li, Yufei Cao, Chengyuan Liu, Jun Ge, Hao Chen, Richard Zare. 2020. "Reaction of chloroauric acid with histidine in microdroplets yields catalytic Au-(His)2 complex." Chemical Science, vol. in press.
Teng Yuan, Pengyi Zhao, Shun Teng, Yaping Yi, Jin Wang, Chuan Shan, Lukasz Wojtas, Jonathan Jean, Hao Chen, Xiaodong Shi. 2020. "Regioselective Crossed Aldol Reactions under Ambient Conditions via Synergistic Gold/Iron Catalysis." Chem (Impact Factor 18.2), pp. in press.
Xiaoqin Zhong, Hao Chen, Richard Zare. 2020. "Ultrafast enzymatic digestion of proteins by microdroplet mass spectrometry." Nature Communications, vol. in press.
Rahul Narayanan, Xiaowei Song, Hao Chen, Richard Zare. 2020. "Teflon Spray Ionization Mass Spectrometry." Journal of American Society for Mass Spectrometry, vol. in press.
Pengyi I. Zhao, Qi Wang, Manpreet Kaur, Yong I. Kim, Howard Dewald, Olivier Mozziconacci, Yong Liu, Hao Chen. 2020. "Absolute Quantitation of Proteins by Coulometric Mass Spectrometry." Analytical Chemistry, vol. 92, pp. 7877-7883.
Karthik Sambath, Zhaoxiong Wan, Qi Wang, Hao Chen, Yuanwei Zhang. 2020. "BODIPY-Based Photoacid Generators for Light-Induced Cationic Polymerization." Organic Letters / American Chemical Society, vol. 22, no. 3, pp. 1208-1212.
Pengyi Zhao, Richard N. Zare, Hao Chen. 2019. "Absolute Quantitation of Oxidizable Peptides Using Coulometric Mass Spectrometry." J. Am. Soc. Mass Spectrom., vol. 30, pp. 2398-2407.
Xiaohan Ye, Pengyi Zhao, Shuyao Zhang, Yanbin Zhang, Qilin Wang, Chuan Shan, Lukasz Wojtas, Hao Guo, Hao Chen, Xiaodong Shi. 2019. "Facilitating Gold Redox Catalysis with Electrochemistry: An Efficient “Chemical-Oxidant-Free” Approach." Angew. Chem. Int. Ed., vol. 58, pp. 17226 –17230 .
Pengyi Zhao, Yong Guo, Howard Dewald, Hao Chen. 2019. "Improvements for Absolute Quantitation Using Electrochemical Mass Spectrometry." International Journal of Mass Spectrometry, vol. 443, pp. 41.
Chengyuan Liu, Jia Li, Hao Chen, Richard N. Zare. 2019. "Scale-Up of Microdroplet Reactions by Heated Ultrasonic Nebulization." Chemical Science, vol. 10, pp. 9367-9373.
Chang Xu, Qiuling Zheng, Joseph Paterson, Hao Chen, Pengyi Zhao. 2019. "A novel chemical quantification method using electrochemical mass spectrometry." Journal of American Society for Mass Spectrometry, vol. 30, pp. 685.
X. Song, Hao Chen, R.N. Zare. 2018. "Conductive polymer spray ionization mass spectrometry for biofluid analysis." Analytical Chemistry, vol. 90, no. 21, pp. 12878-12885.
M. Lu, Y. Su, P. Zhao, X. Ye, Y. Cai, X. Shi, E. Masson, F. Li, J.L. Campbell, Hao Chen. 2018. "Direct evidence for the origin of bis-gold intermediates: Probing gold catalysis with mass spectrometry." Chemistry - A European Journal, vol. 24, no. 9, pp. 2144-2150.
M. Nshanian, R. Lakshmanan, Hao Chen, R.R.O. Loo, J.A. Loo. 2018. "Enhancing sensitivity of liquid chromatography-mass spectrometry of peptides and proteins using supercharging agents." International Journal of Mass Spectrometry, vol. 427, pp. 157-164.
J. Wang, S. Zhang, C. Xu, L. Wojtas, N.G. Akhmedov, Hao Chen, X. Shi. 2018. "Highly efficient and stereoselective thioallylation of alkynes: Possible gold redox catalysis with no need for a strong oxidant." Angewandte Chemie - International Edition, vol. 57, no. 23, pp. 6915-6920.
Q. Zheng, Y. Tian, X. Ruan, Hao Chen, X. Wu, X. Xu, G. Wang, H. Hao, H. Ye. 2018. "Probing specific ligand-protein interactions by native-denatured exchange mass spectrometry." Analytica Chimica Acta, vol. 1036, pp. 58-65.
Z. Chen, Z. Jiang, N. Chen, Q. Shi, L. Tong, F. Kong, X. Cheng, Hao Chen, C. Wang, B. Tang. 2018. "Target discovery of ebselen with a biotinylated probe." Chemical Communications, vol. 54, no. 68, pp. 9506-9509.
P. Liu, P. Zhao, R. Graham Cooks, Hao Chen. 2017. "Atmospheric pressure neutral reionization mass spectrometry for structural analysis." Chemical Science, vol. 8, no. 9, pp. 6499-6507.
Y. Cai, J. Wang, Y. Zhang, Z. Li, D. Hu, N. Zheng, Hao Chen. 2017. "Detection of fleeting amine radical cations and elucidation of chain processes in visible-light-mediated [3 + 2] annulation by online mass spectrometric techniques." Journal of the American Chemical Society, vol. 139, no. 35, pp. 12259-12266.
S. Cheng, Q. Wu, H. Xiao, Hao Chen. 2017. "Online monitoring of enzymatic reactions using time-resolved desorption electrospray ionization mass spectrometry." Analytical Chemistry, vol. 89, no. 4, pp. 2338-2344.
S. Cheng, Q. Wu, H.D. Dewald, Hao Chen. 2017. "Online monitoring of methanol electro-oxidation reactions by ambient mass spectrometry." Journal of the American Society for Mass Spectrometry, vol. 28, no. 6, pp. 1005-1012.
Q. Wu, S. Cheng, Hao Chen, C. Wang. 2017. "ZIF-67 Templated synthesis of nanoporous carbon as an efficient adsorbent for preconcentration of flunitrazepam from beverage samples." Food Analytical Methods, vol. 10, no. 8, pp. 2772-2780.
Y. Cai, P. Liu, M.A. Held, H.D. Dewald, Hao Chen. 2016. "Coupling electrochemistry with probe electrospray ionization mass spectrometry." ChemPhysChem, vol. 17, no. 8, pp. 1104-1108.
Q. Zheng, Hao Chen. 2016. "Development and applications of liquid sample desorption electrospray ionization mass spectrometry." Annual Review of Analytical Chemistry, vol. 9, pp. 411-448.
Q. Wu, S. Cheng, Z. Li, Hao Chen. 2016. "Highly sensitive mass spectrometric detection of flunitrazepam using magnetic graphene framework enrichment." Analytical Methods, vol. 8, no. 32, pp. 6168-6175.
Z. Li, S. Zhang, Y. Cai, Q. Wu, Hao Chen. 2016. "Hollow fiber-based solid-liquid phase microextraction combined with theta capillary electrospray ionization mass spectrometry for sensitive and accurate analysis of methamphetamine." Analytical Methods, vol. 8, no. 43, pp. 7800-7807.
H. Peng, R. Cai, C. Xu, Hao Chen, X. Shi. 2016. "Nucleophile promoted gold redox catalysis with diazonium salts: C-Br, C-S and C-P bond formation through catalytic Sandmeyer coupling." Chemical Science, vol. 7, no. 9, pp. 6190-6196.
T.A. Brown, N. Hosseini-Nassab, Hao Chen, R.N. Zare. 2016. "Observation of electrochemically generated nitrenium ions by desorption electrospray ionization mass spectrometry." Chemical Science, vol. 7, no. 1, pp. 329-332.
Z. Ding, M. Jiang, Hao Chen, Z. Jin, Mengchu Zhou. 2016. "Petri net based test case generation for evolved specification." Science China Information Sciences, vol. 59, no. 8.
Q. Zheng, H. Zhang, S. Wu, Hao Chen. 2016. "Probing protein 3D structures and conformational changes using electrochemistry-assisted isotope labeling cross-linking mass spectrometry." Journal of the American Society for Mass Spectrometry, vol. 27, no. 5, pp. 864-875.
X. Ye, C. Xu, L. Wojtas, N.G. Akhmedov, Hao Chen, X. Shi. 2016. "Silver-free palladium-catalyzed sp3 and sp2 C-H alkynylation promoted by a 1,2,3-triazole amine directing group." Organic Letters, vol. 18, no. 12, pp. 2970-2973.
L. Li, X. Wang, Q. Li, P. Liu, K. Xu, Hao Chen, B. Tang. 2015. "An accurate mass spectrometric approach for the simultaneous comparison of GSH, Cys, and Hcy in L02 cells and HepG2 cells using new NPSP isotope probes." Chemical Communications, vol. 51, no. 56, pp. 11317-11320.
Q. Zheng, Y. Liu, Q. Chen, M. Hu, R. Helmy, E.C. Sherer, C.J. Welch, Hao Chen. 2015. "Capture of reactive monophosphine-ligated palladium(0) intermediates by mass spectrometry." Journal of the American Chemical Society, vol. 137, no. 44, pp. 14035-14038.
T.A. Brown, Hao Chen, R.N. Zare. 2015. "Detection of the short-lived radical cation intermediate in the electrooxidation of N,N-Dimethylaniline by mass spectrometry." Angewandte Chemie - International Edition, vol. 54, no. 38, pp. 11183-11185.
S. Cheng, J. Wang, Y. Cai, J.A. Loo, Hao Chen. 2015. "Enhancing performance of liquid sample desorption electrospray ionization mass spectrometry using trap and capillary columns." International Journal of Mass Spectrometry, vol. 392, pp. 73-79.
F. Kong, B. Hu, Y. Gao, K. Xu, X. Pan, F. Huang, Q. Zheng, Hao Chen, B. Tang. 2015. "Fluorescence imaging of selenol in HepG2 cell apoptosis induced by Na2SeO3." Chemical Communications, vol. 51, no. 15, pp. 3102-3105.
T.A. Brown, Hao Chen, R.N. Zare. 2015. "Identification of fleeting electrochemical reaction intermediates using desorption electrospray ionization mass spectrometry." Journal of the American Chemical Society, vol. 137, no. 23, pp. 7274-7277.
Y. Cai, Q. Zheng, Y. Liu, R. Helmy, J.A. Loo, Hao Chen. 2015. "Integration of electrochemistry with ultraperformance liquid chromatography/mass spectrometry." European Journal of Mass Spectrometry, vol. 21, no. 3, pp. 341-351.
R. Cai, M. Lu, E.Y. Aguilera, Y. Xi, N.G. Akhmedov, J.L. Petersen, Hao Chen, X. Shi. 2015. "Ligand-assisted gold-catalyzed cross-coupling with aryldiazonium salts: Redox gold catalysis without an external oxidant." Angewandte Chemie - International Edition, vol. 54, no. 30, pp. 8772-8776.
P. Liu, R.G. Cooks, Hao Chen. 2015. "Nuclear magnetic resonance structure elucidation of peptide b2 ions." Angewandte Chemie - International Edition, vol. 54, no. 5, pp. 1547-1550.
P. Liu, Q. Zheng, H.D. Dewald, R. Zhou, Hao Chen. 2015. "The study of electrochemistry with ambient mass spectrometry." TrAC - Trends in Analytical Chemistry, vol. 70, pp. 20-30.
Y. Cai, D. Adams, Hao Chen. 2014. "A new splitting method for both analytical and preparative LC/MS." Journal of the American Society for Mass Spectrometry, vol. 25, no. 2, pp. 286-292.
Y. Cai, Y. Liu, R. Helmy, Hao Chen. 2014. "Coupling of ultrafast LC with mass spectrometry by DESI." Journal of the American Society for Mass Spectrometry, vol. 25, no. 10, pp. 1820-1823.
Q. Zheng, H. Zhang, L. Tong, S. Wu, Hao Chen. 2014. "Cross-linking electrochemical mass spectrometry for probing protein three-dimensional structures." Analytical Chemistry, vol. 86, no. 18, pp. 8983-8991.
P. Liu, A. Forni, Hao Chen. 2014. "Development of solvent-free ambient mass spectrometry for green chemistry applications." Analytical Chemistry, vol. 86, no. 8, pp. 4024-4032.
Y. Su, M. Lu, B. Dong, Hao Chen, X. Shi. 2014. "Silver-catalyzed alkyne activation: The surprising ligand effect." Advanced Synthesis and Catalysis, vol. 356, no. 4, pp. 692-696.
N. Pan, P. Liu, W. Cui, B. Tang, J. Shi, Hao Chen. 2013. "Highly efficient ionization of phosphopeptides at low pH by desorption electrospray ionization mass spectrometry." Analyst, vol. 138, no. 5, pp. 1321-1324.
Q. Zheng, H. Zhang, Hao Chen. 2013. "Integration of online digestion and electrolytic reduction with mass spectrometry for rapid disulfide-containing protein structural analysis." International Journal of Mass Spectrometry, vol. 353, pp. 84-92.
P. Liu, J. Zhang, C.N. Ferguson, Hao Chen, J.A. Loo. 2013. "Measuring protein-ligand interactions using liquid sample desorption electrospray ionization mass spectrometry." Analytical Chemistry, vol. 85, no. 24, pp. 11966-11972.
M. Lu, J.L. Campbell, R. Chauhan, C.A. Grapperhaus, Hao Chen. 2013. "Probing the reactivity and radical nature of oxidized transition metal-thiolate complexes by mass spectrometry." Journal of the American Society for Mass Spectrometry, vol. 24, no. 4, pp. 502-512.
P. Liu, M. Lu, Q. Zheng, Y. Zhang, H.D. Dewald, Hao Chen. 2013. "Recent advances of electrochemical mass spectrometry." Analyst, vol. 138, no. 19, pp. 5519-5539.
E. Weldy, C. Wolff, Z. Miao, Hao Chen. 2013. "Selective and sensitive detection of chromium(VI) in waters using electrospray ionization mass spectrometry." Science and Justice, vol. 53, no. 3, pp. 293-300.
Y. Zhang, W. Cui, H. Zhang, H.D. Dewald, Hao Chen. 2012. "Electrochemistry-assisted top-down characterization of disulfide-containing proteins." Analytical Chemistry, vol. 84, no. 8, pp. 3838-3842.
Z. Wang, Y. Zhang, H. Zhang, P.B. Harrington, Hao Chen. 2012. "Fast and selective modification of thiol proteins/peptides by N-(phenylseleno) phthalimide." Journal of the American Society for Mass Spectrometry, vol. 23, no. 3, pp. 520-529.
M. Lu, C. Wolff, W. Cui, Hao Chen. 2012. "Investigation of some biologically relevant redox reactions using electrochemical mass spectrometry interfaced by desorption electrospray ionization." Analytical and Bioanalytical Chemistry, vol. 403, no. 2, pp. 355-365.
P. D'Aloise, Hao Chen. 2012. "Rapid determination of flunitrazepam in alcoholic beverages by desorption electrospray ionization-mass spectrometry." Science and Justice, vol. 52, no. 1, pp. 2-8.
Y. Liu, Z. Miao, R. Lakshmanan, R.R.O. Loo, J.A. Loo, Hao Chen. 2012. "Signal and charge enhancement for protein analysis by liquid chromatography-mass spectrometry with desorption electrospray ionization." International Journal of Mass Spectrometry, vol. 325-327, pp. 161-166.
Z. Chen, Q. Li, Q. Sun, Hao Chen, X. Wang, N. Li, M. Yin, Y. Xie, H. Li, B. Tang. 2012. "Simultaneous determination of reactive oxygen and nitrogen species in mitochondrial compartments of apoptotic HepG2 cells and PC12 cells based on microchip electrophoresis-laser-induced fluorescence." Analytical Chemistry, vol. 84, no. 11, pp. 4687-4694.
P. Liu, I.T. Lanekoff, J. Laskin, H.D. Dewald, Hao Chen. 2012. "Study of electrochemical reactions using nanospray desorption electrospray ionization mass spectrometry." Analytical Chemistry, vol. 84, no. 13, pp. 5737-5743.
Y. Zhang, Z. Yuan, H.D. Dewald, Hao Chen. 2011. "Coupling of liquid chromatography with mass spectrometry by desorption electrospray ionization (DESI)." Chemical Communications, vol. 47, no. 14, pp. 4171-4173.
X. Sun, Z. Miao, Z. Yuan, P.D.B. Harrington, J. Colla, Hao Chen. 2011. "Coupling of single droplet micro-extraction with desorption electrospray ionization-mass spectrometry." International Journal of Mass Spectrometry, vol. 301, no. 1-3, pp. 102-108.
Z. Miao, Hao Chen, P. Liu, Y. Liu. 2011. "Development of submillisecond time-resolved mass spectrometry using desorption electrospray ionization." Analytical Chemistry, vol. 83, no. 11, pp. 3994-3997.
C.N. Ferguson, S.A. Benchaar, Z. Miao, J.A. Loo, Hao Chen. 2011. "Direct ionization of large proteins and protein complexes by desorption electrospray ionization-mass spectrometry." Analytical Chemistry, vol. 83, no. 17, pp. 6468-6473.
Y. Zhang, H.D. Dewald, Hao Chen. 2011. "Online mass spectrometric analysis of proteins/peptides following electrolytic cleavage of disulfide bonds." Journal of Proteome Research, vol. 10, no. 3, pp. 1293-1304.
Y. Zhang, H. Zhang, W. Cui, Hao Chen. 2011. "Tandem MS analysis of selenamide-derivatized peptide ions." Journal of the American Society for Mass Spectrometry, vol. 22, no. 9, pp. 1610-1621.
Y. Zhang, Hao Chen. 2010. "Detection of saccharides by reactive desorption electrospray ionization (DESI) using modified phenylboronic acids." International Journal of Mass Spectrometry, vol. 289, no. 2-3, pp. 98-107.
K. Xu, Y. Zhang, B. Tang, J. Laskin, P.J. Roach, Hao Chen. 2010. "Study of highly selective and efficient thiol derivatization using selenium reagents by mass spectrometry." Analytical Chemistry, vol. 82, no. 16, pp. 6926-6932.
B.C. Gau, Hao Chen, Y. Zhang, M.L. Gross. 2010. "Sulfate radical anion as a new reagent for fast photochemical oxidation of proteins." Analytical Chemistry, vol. 82, no. 18, pp. 7821-7827.
Z. Miao, S. Wu, Hao Chen. 2010. "The study of protein conformation in solution via direct sampling by desorption electrospray ionization mass spectrometry." Journal of the American Society for Mass Spectrometry, vol. 21, no. 10, pp. 1730-1736.
Z. Miao, Hao Chen. 2009. "Direct analysis of liquid samples by desorption electrospray ionization-mass spectrometry (DESI-MS)." Journal of the American Society for Mass Spectrometry, vol. 20, no. 1, pp. 10-19.
J. Li, H.D. Dewald, Hao Chen. 2009. "Online coupling of electrochemical reactions with liquid sample desorption electrospray ionization-mass spectrometry." Analytical Chemistry, vol. 81, no. 23, pp. 9716-9722.
W. Lu, C.F. László, Z. Miao, Hao Chen, S. Wu. 2009. "The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the α subunit of eukaryotic initiation factor 2." Journal of Biological Chemistry, vol. 284, no. 36, pp. 24281-24288.
L.S. Eberlin, Y. Xia, Hao Chen, R.G. Cooks. 2008. "Atmospheric pressure thermal dissociation of phospho- and sulfopeptides." Journal of the American Society for Mass Spectrometry, vol. 19, no. 12, pp. 1897-1905.
I. Cotte-Rodríguez, H. Hernández-Soto, Hao Chen, R.G. Cooks. 2008. "In situ trace detection of peroxide explosives by desorption electrospray ionization and desorption atmospheric pressure chemical ionization." Analytical Chemistry, vol. 80, no. 5, pp. 1512-1519.
Hao Chen, L.S. Eberlin, M. Nefliu, R. Augusti, R.G. Cooks. 2008. "Organic reactions of ionic intermediates promoted by atmospheric-pressure thermal activation." Angewandte Chemie - International Edition, vol. 47, no. 18, pp. 3422-3425.
W.-P. Peng, M.P. Goodwin, Hao Chen, R.G. Cooks, J. Wilker. 2008. "Thermal formation of mixed-metal inorganic complexes at atmospheric pressure." Rapid Communications in Mass Spectrometry, vol. 22, no. 22, pp. 3540-3548.
Hao Chen, Yuegang Zuo. 2007. "Identification of flavonol glycosides in American cranberry fruit." Food Chemistry, vol. 101, pp. 1357-1364.
Hao Chen, L.S. Eberlin, R.G. Cooks. 2007. "Neutral fragment mass spectra via ambient thermal dissociation of peptide and protein ions." Journal of the American Chemical Society, vol. 129, no. 18, pp. 5880-5886.
G. Huang, Hao Chen, X. Zhang, R.G. Cooks, Z. Ouyang. 2007. "Rapid screening of anabolic steroids in urine by reactive desorption electrospray ionization." Analytical Chemistry, vol. 79, no. 21, pp. 8327-8332.
R. Augusti, Hao Chen, L.S. Eberlin, M. Nefliu, R.G. Cooks. 2006. "Atmospheric pressure Eberlin transacetalization reactions in the heterogeneous liquid/gas phase." International Journal of Mass Spectrometry, vol. 253, no. 3, pp. 281-287.
Hao Chen, I. Cotte-Rodríguez, R.G. Cooks. 2006. "cis-Diol functional group recognition by reactive desorption electrospray ionization (DESI)." Chemical Communications, vol. 6, no. 6, pp. 597-599.
Daniel J Goebbert, Hao Chen, Paul G Wenthold. 2006. "Collision‐induced dissociation studies of protonated ether—(H2O)n (n = 1–3) clusters." Journal of Mass Spectrometry, vol. 41, pp. 242-247.
Yiwei Deng, Kai Zhang, Hao Chen, Taixing Wu, Metthew Krzyaniak, Amina Wellons, Dawn Bolla, Kenneth Douglas, Yuegang Zuo. 2006. "Iron-catalyzed photochemical transformation of benzoic acid in atmospheric liquids: Product identification and reaction mechanisms." Atmospheric Environment, vol. 40, pp. 3665-3676.
R.G. Cooks, Hao Chen, M.N. Eberlin, X. Zheng, W.A. Tao. 2006. "Polar acetalization and transacetalization in the gas phase: The Eberlin reaction." Chemical Reviews, vol. 106, no. 1, pp. 188-211.
I. Cotte-Rodríguez, Hao Chen, R.G. Cooks. 2006. "Rapid trace detection of triacetone triperoxide (TATP) by complexation reactions during desorption electrospray ionization." Chemical Communications, no. 9, pp. 953-955.
Hao Chen, Z. Ouyang, R.G. Cooks. 2006. "Thermal production and reactions of organic ions at atmospheric pressure." Angewandte Chemie - International Edition, vol. 45, no. 22, pp. 3656-3660.
I.A. Popov, Hao Chen, O.N. Kharybin, E.N. Nikolaev, R.G. Cooks. 2005. "Detection of explosives on solid surfaces by thermal desorption and ambient ion/molecule reactions." Chemical Communications, no. 15, pp. 1953-1955.
Hao Chen, R.G. Cooks, E.C. Meurer, M.N. Eberlin. 2005. "Hydrogen/chlorine exchange reactions of gaseous carbanions." Journal of the American Society for Mass Spectrometry, vol. 16, no. 12, pp. 2045-2051.
Hao Chen, R. Xu, Hao Chen, R.G. Cooks, Z. Ouyang. 2005. "Ion/molecule reactions in a miniature RIT mass spectrometer." Journal of Mass Spectrometry, vol. 40, no. 11, pp. 1403-1411.
Hao Chen, D.R. Justes, R.G. Cooks. 2005. "Proton affinities of N-heterocyclic carbene super bases." Organic Letters, vol. 7, no. 18, pp. 3949-3952.
Y. Song, Hao Chen, R.G. Cooks. 2005. "Reactivity of acetonyl anion with nitroaromatics: An atmospheric pressure chemical ionization study." Rapid Communications in Mass Spectrometry, vol. 19, no. 23, pp. 3493-3499.
H. Bagheri, Hao Chen, R.G. Cooks. 2004. "Chiral recognition by proton transfer reactions with optically active amines and alcohols." Chemical Communications, no. 23, pp. 2740-2741.
R. Augusti, M. Turowski, Hao Chen, R.G. Cooks. 2004. "Dissociation of ionized benzophenones investigated by the kinetic method: Effective temperature, steric effects and gas-phase CO+. affinities of phenyl radicals." Journal of Mass Spectrometry, vol. 39, no. 5, pp. 558-564.
R. Augusti, D.V. Augusti, Hao Chen, R.G. Cooks. 2004. "Gas-phase halide affinity of aliphatic alcohols estimated by the kinetic method." European Journal of Mass Spectrometry, vol. 10, no. 6, pp. 847-855.
E.C. Meurer, Hao Chen, L. Riter, I. Cotte-Rodriguez, M.N. Eberlin, R.G. Cooks. 2004. "Gas-phase reactions for selective detection of the explosives TNT and RDX." Chemical Communications, vol. 4, no. 1, pp. 40-41.
Hao Chen, Hao Chen, R.G. Cooks, H. Bagheri. 2004. "Generation of arylnitrenium ions by nitro-reduction and gas-phase synthesis of N-heterocycles." Journal of the American Society for Mass Spectrometry, vol. 15, no. 11, pp. 1675-1688.
E.C. Meurer, Hao Chen, L.S. Riter, R.G. Cooks, M.N. Eberlin. 2004. "Meerwein reaction of phosphonium ions with epoxides and thioepoxides in the gas phase." Journal of the American Society for Mass Spectrometry, vol. 15, no. 3, pp. 398-405.
Hao Chen, Hao Chen, R.G. Cooks. 2004. "Meisenheimer complexes bonded at carbon and at oxygen." Journal of the American Society for Mass Spectrometry, vol. 15, no. 7, pp. 998-1004.
Hao Chen, X. Zheng, P. Yang, R.G. Cooks. 2004. "Reduction of nitroaromatics to arylnitrenium ions by vinyl halide cations." Chemical Communications, vol. 10, no. 6, pp. 688-689.
Leah S Riter, Eduardo C Meurer, Eric S Handberg, Brian C Laughlin, Hao Chen, Garth E Patterson, R Graham Cooks. 2003. "Ion/molecule reactions performed in a miniature cylindrical ion trap mass spectrometer." Analyst, vol. 28, pp. 1112-1118.
Hao Chen, X. Zheng, R.G. Cooks. 2003. "Ketalization of phosphonium ions by 1,4-dioxane: Selective detection of the chemical warfare agent simulant DMMP in mixtures using ion/molecule reactions." Journal of the American Society for Mass Spectrometry, vol. 14, no. 3, pp. 182-188.
Yuegang Zuo, Hao Chen. 2003. "Simultaneous determination of sulfite, sulfate, and hydroxymethanesulfonate in atmospheric waters by ion-pair HPLC technique." Talenta, vol. 59, pp. 875-881.
Yuegang Zuo, Hao Chen, Yiwei Deng. 2002. "Simultaneous determination of catechins, caffeine and gallic acids in green, Oolong, black and pu-erh teas using HPLC with a photodiode array detector." Talenta, vol. 57, pp. 307-316.
Yonggang Yang, Hao Chen, Geng Tang, Jianxun Wen. 2002. "Synthesis and mesomorphic properties of several series of fluorinated ester liquid crystals." Liquid Crystals, vol. 29, pp. 255-261.
Yonggang Yang, Hao Chen, Geng Tang, Jianxun Wen. 2002. "Synthesis and mesomorphic properties of some fluorinated benzoate liquid crystals." Molecular Crystals and Liquid Crystals, vol. 373, pp. 1-15.
Hao Chen, Yuegang Zuo, Yiwei Deng. 2001. "Separation and determination of flavonoids and other phenolic compounds in cranberry juice by high-performance liquid chromatography." Journal of Chromatography A, vol. 913, pp. 387-395.
Jianxun Wen, Hao Chen, Yuehai Shen. 1999. "The first series of ferroelectric steroidal fluorinated liquid crystals." Liquid Crystals, vol. 26, pp. 1833-1834.
Book Review
"Technical and Methodological Advances in Proteomics"
Frontiers in Chemistry, 2021.
Frontiers in Chemistry, 2021.
"Review of "Mass spectrometry instrumentation, interpretation, and applications""
Journal of the American Society for Mass Spectrometry, 2010.
Journal of the American Society for Mass Spectrometry, 2010.
Conference Proceeding
"Resource-oriented petri net-based approach to deadlock prevention of AMSs"
Proceedings - 2015 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2015, 2016.
Proceedings - 2015 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2015, 2016.
Book
I. Cotte-Rodriguez, Z. Miao, Y. Zhang, Hao Chen. "Introduction to protein mass spectrometry." 1-58 pp. Characterization of Protein Therapeutics using Mass Spectrometry, 2013.
I. Cotte-Rodriguez, Y. Zhang, Z. Miao, Hao Chen. "Ionization methods in protein mass spectrometry." 1-42 pp. Protein and Peptide Mass Spectrometry in Drug Discovery, 2011.
Hao Chen, J. Li. "Rapid analysis of drug-related substances using desorption electrospray ionization and direct analysis in real time ionization mass spectrometry." 81-108 pp. Characterization of Impurities and Degradants Using Mass Spectrometry, 2011.
Hao Chen. "Historical perspectives in the study of ion chemistry by mass spectrometry: From the gas phase to solution." 37-62 pp. Reactive Intermediates: MS Investigations in Solution, 2010.